Characterization of Ceiba petandra and Lannea kerstingii Stem Bark Extract Creams
Journal Title: Journal of Pharmaceutical & Health Sciences - Year 2017, Vol 5, Issue 1
Abstract
A study on physicochemical characteristics of Ceiba petandra and Lannea kerstingii stem bark extracts cream, being developed for the treatment of topical dermatophyte infections, has been carried out to assure its safety, effectiveness, and stability during storage and usage. The stem barks of Ceiba petandra and Lannea kerstingii were extracted with methanol and ethyl acetate respectively. The obtained extracts and their combinations were formulated into creams using modified Aqueous Cream BP base at concentrations ranging from 0.4 to 3.2%w/w. Physical and chemical characteristics of the creams such as stability, viscosity, pH, diffusion, irritancy and elegance were evaluated. Ketoconazole cream was used as the reference product. Creams prepared with each extract alone exhibited favorable characteristics in terms of spreadability, non-irritancy, stability, and diffusivity. Creams formulated with Ceiba petandra were most stable with pH ranges of 6.21 to 7.13. Those formulated with Lannea kerstingii were more acidic. Creams formulated with the combinations of the two extracts exhibited some levels of incompatibility, which increased with increasing extract concentrations. The rate of diffusion of the extracts from cream base increased with time and was generally more at 37 ºC as compared to that at 25 ºC. Cream formulations of the stem bark extracts of Ceiba petandra and Lannea kerstingii, but not their combinations using modified Aqueous Cream (BP), possess satisfactory physicochemical characteristics.
Authors and Affiliations
Olusola Isaac Aremu, Adeola Tawakalitu Kola-Mustapha, Taiye Hameedat Ayotunde
Keywords
Related Articles
- EP ID EP215201
- DOI -
- Views 164
- Downloads 0
Nutritive Value and Mineral Elements of Wild Astragalus meridioalis sensu auct. Seeds in South of Iran
Literature survey revealed that there was no biological investigation on Astragalus meridioalis sensu auct. seeds worldwide. The mature seeds of A. meridioalis was collected in August 2015 from...
Analog kefir production with a low phenylalanine for Phenylketonuria
Phenylketonuria (PKU) is one of the most prevalent types of hereditary metabolic disorders which is caused due to an absence or reduction of the activity of the Phenylalanine hydroxylase enzyme in the liver which in turn...
Levels of Mercury in Persian Gulf Frozen Fish Species
Severe discharge of sewage and industrial effluents into the Persian Gulf leads to the deposition of various types of heavy metals, especially lead and mercury, in the muscles of fish. Total mercury and methylmercury con...
Quality Characteristics of Iranian Extra Virgin Flaxseed Oil and the Effect of the Refining Stages before Deodorization on its Physicochemical Properties
Flaxseed oil is known as a functional oil because of the high content of α-linolenic acid; therefore, the aim of this research was to investigate some physicochemical properties of Iranian extra virgin flaxseed oil (EVFO...
Preparation of Alprazolam Extended- Release Tablets and In vitro Characterization
The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studi...