Characterization of prescription and OTC formulations of vidarabine cream
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 1
Abstract
The aim of this study, to assess the uniformity of content, viscosity, spreadability, near-infrared absorption spectroscopy and water content of vidarabine cream (Ara-A: bland name, Ara-B: generic and Ara-C: Over the Counter). Moreover, this study assessed the physicochemical properties of the creams. The Uniformity test indicated that the VDN content was uniform and equivalence was observed. As results of viscosity, Ara-B differed from those in Ara-A and Ara-C. The yield value was calculated based on measured flattening and was 1109.8 dynes/cm2 for Ara-A, 527.7 dynes/cm2 for Ara-B, 1200.1 dynes/cm2 for Ara-C. Measurement of water content revealed that Ara-A, and -C had water content of around 56.3%, Ara-B had water content of 59.9%. NIR absorption spectroscopy revealed that Ara-B had the highest absorption peak due to hydroxyl groups, followed by Ara-A, then -C. In order to evaluate the feel on the skin, friction generated by Ara-A and-C was around 90 N, Ara-B was 54.4 N. The drug spread is good about the skin friction, spreadability might be affecting the human sensory.
Authors and Affiliations
Dr. Yutaka Inoue
Keywords
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