Characterization, Stability And Anti-Inflammatory Efficacy Of Aceclofenac Eye Drops
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
Non steroidal anti-inflammatory drugs (NSAIDs) used to be the mainstay of topical therapy in the management of ocular inflammations. Aceclofenac (ACF) possesses better analgesic, antipyretic and antiinflammatory efficacy than other NSAIDs. Aceclofenac eye drop is not available in the market so this study is considered as a novel approach to formulate ACF eye drops to reduce eye inflammation. The goal of the present study was to formulate ACF eye drop using different polymers such as hydroxypropyl methylcellulose (HPMC), capobol 934 (CP 934) and sodium alginate (S. Alg). These formulae were evaluted with respect to drug content, pH, viscosity, in-vitro release, and stability for 6 months. Kinetic analysis of the release data was done. The efficacy of the selected formulation (FI) against prostaglandin E1 (PGE1) induced ocular inflammation in rabbit's eye was determined by counting the polymorphonuclear leukocytes (PMN) migrated in tear fluid. Collectively, all formulations exhibited accepted drug content, pH, and viscosity values. The drug release was varied with polymer type in the order of HPMC > CP 934 > S. Alg. Also, HPMC eye drops (FI) exhibited the greatest stability after 6 months. Considering the anti-inflmmatory efficacy, HPMC eye drops (FI) showed a significant inhibition of PGE1-induced (PMN) migration as compared to control formula.
Authors and Affiliations
Osama A. Soliman, Marwa S. El-Dahan, Sara N. Maria
Keywords
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- EP ID EP394516
- DOI 10.9790/3008-1302040713
- Views 58
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