CHEMICAL-QUANTUM ANALYSIS OF THE BIOLOGICAL ACTIVITY OF BIOACTIVE DIPEPTIDS FOR THE POSSIBLE TREATMENT OF DIABETES
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 7
Abstract
Currently, public health problems in developed countries are focused on the aging of the population and the increase in the prevalence of certain chronic diseases. Chronic diseases have been overtaken by noncommunicable diseases "typical lifestyle diseases"; such as high blood pressure, obesity, or diabetes. The objective of this work was to analyze the chemical-quantum interactions of glucose with each of the amino acids (AA) that makeup insulin. The Hyperchem simulator was used to perform quantum calculations. These calculations are based on the theory of the electron transfer coefficient (ETC) published in other articles. We found that Arginine and Histidine adhere more easily to glucose. It is probable that these AAs and their dipeptides act positively in the treatment of diabetes as growth adjuvants for the maintenance of muscle tissue since they adhere to the active site of insulin, preventing glucose from increasing. We concluded that: A) Arginine and histidine have the lowest ETC of all interactions of the AAs that make up insulin. For this reason, these two AAs determine the active site of insulin for glucose. B) The dipeptides derived from arginine and histidine (approximately 40) are related to the active site of insulin. These dipeptides have the potential to help cells use glucose as an energy source and decrease hyperglycemia in diabetes.
Authors and Affiliations
Manuel González-Pérez
Keywords
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