Abstract

In humans, the NFE2L2/AP-1 pathway controls more than 5% of the protein-coding genes. This pathway is responsible for cellular reactions towards ROS, xenobiotics, highly reactive substances of various nature, drug resistance and a plethora of other intracellular, intercellular and microenvironment functions. The great diversity of the pathway functions is astonishing and raises questions of how the pathway operates to provide the cell with specific enough reactions. The present review focuses on current knowledge in the field. Today, the pathway functioning is already used in developing novel pharmaceutics and diagnostics approaches, in therapy follow-up. Filling the existing blanc spots of the NFE2L2/AP-1 interactome would significantly advance the related fields and open new horizons in medical technologies.

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