Chemokines Profile in Patients with Graves Diseases in Comparison to Nonautoimmune Hyperthyroidism in Al-Najaf Province
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Graves' disease (GD), a form of hyperthryroidism (overactive thyroid gland), typified by auto antibodies directed against the thyroid stimulating hormone receptor (TSHR), Thyroid peroxidase (TPO) and thyroglobulin (Tg) (Hammerstad and tomer, 2015; Giménez-Barcons et al., 2015). The presence of thyroid autoantibodies substantially contributes to the pathogenesis of a number of thyroid disorders, such as Hashimoto’s thyroiditis, primary myxedema and Graves’ disease (Xander et al., 2012). They are also present in a smaller percentage of sera from other non- autoimmune thyroid disorders. Thyroid autoantibodies in autoimmune thyroid diseases have been reported to range from 1-40% but its prevalence in non-autoimmune diseases is unknown (Elmugadam et al., 2014). Autoimmune thyroid Graves' disease is one of the most common autoimmune disease (AID), affecting 13 million people and targeting women seven times as often as men. It most often affects young to middle-aged adults but can occur at all ages. (Vos et al.,2009; Utiger,2015).
Authors and Affiliations
Dr Kareemthamir Mashkoor Al-Kaabi
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