Chemometric Determination of Memantine and Donepezil Active Ingredients Used in the Treatment of Alzheimer's Disease by Evaluation of Spectrophotometric Data
Journal Title: Rahva Journal of Technical and Social Studies - Year 2021, Vol 1, Issue 2
Abstract
In this study, which was conducted to analyze the drug sample used in Alzheimer's treatment containing memantine and donepezil, UV Visible Spectroscopy was used together with the chemometry determination method. The ultraviolet spectra of the active ingredients of memantine and donepezil were measured and recorded, they were found to be of workable purity and analysis was carried out. In the method we applied, the mean percent (%) recovery for memantine and donepezil was calculated for the synthetic mixture and for the drug sample. The calculated values are quite high. The results obtained from the PLS and PCR calibration techniques used were controlled by the ANOVA test. The developed methods are one of the reproducible, sensitive and accurate methods and can be recommended for the analysis of drug samples containing memantine and donepezil.
Authors and Affiliations
Güzide PEKCAN ERTOKUŞ, Burak Hasan AKDUMANLI
Keywords
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