Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 6
Abstract
Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of deaths, especially in western countries. Its etiology is known to be a combination of hereditary, environmental, dietary factors and lack of physical activity. Chemoprevention through dietary intervention is an emerging option to reduce mortality due to colon cancer. The present study was aimed to investigate the chemopreventive potential of different doses of Ferula asafoetida oleo-gum-resin on 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis by evaluating tumor multiplicity, tumor incidence, and tumor size, Serum total sialic acid levels as well as histoarchitecture of colons of rats subjected to various treatment. Rats were randomly divided into six groups. Group I rats served as control. Group 2 rats received DMH (30 mg/kg body weight (bw)) for 16 weeks. Group 3-5 animals received asafoetida daily at a dose level of 5mg/100gm bw, 10mg/100gm bw and 20mg/100gm bw respectively along with weakly DMH injections. Group 6 rats received asafoetida daily (20mg/100g bw daily) for 16 weeks. Increased tumor incidence and multiplicity was observed in DMH treated rats which were decreased with asafoetida supplementation. Asafoetida at the dose of 10mg/100gm bw had shown profound beneficial effects by exhibiting near normal Total Sialic Acid levels and well-preserved colon histology. These findings suggest that asafoetida dose 10mg/100g bw is minimum dose with maximum protection for colon cancer.
Authors and Affiliations
Rupali Panwar, Prof. Satyavati Rana, Prof. Davinder Kumar Dhawan, Prof. Kaushal Kishore Prasad
Attenuation of depression on sub acute administration of Terminalia bellerica fruit in tail suspension test
Objective: The present study was undertaken to evaluate the sub acute antidepressant activity of aqueous extract of Terminalia Bellerica (AETB) fruit pulp in the tail suspension test (TST) as a model of depression in a...
Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis
Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of deaths, especially in western countries. Its etiology is known to be a combination of hereditary, environmental,...
Pharmacological and phytochemical studies on Acacia modesta Wall; A review
The use of plants with therapeutic properties is as ancient as human civilization. Acacia modesta belongs to family Fabaceae and is a deciduous tree which has medium or small size. Traditionally, it has been used to tr...
Pharmacognostical and Pharmaceutical evaluation of Herbo mineral Formulation: Aragvadhadi taila
Background: Aragvadhadi taila is a Sneha Kalpana, indicated in Kushtha Roga specially in Shvitra (Vitiligo) Roga. In present study, it has been used for external application in Shvitra (Vitiligo) Roga. Objective: Prese...
Antimicrobial activity of some plant species used for the medical purpose in Turkey
İn this study, the antimicrobial activities of eight species plants, used for treatment of various diseases, were investigated. The extracts of Rhus coriaria L., Pistacia terebinthus L. subsp. palestina, Centaurea virga...