Chemotherapy for Osteosarcoma in Pregnancy - Case Study and Review of Literature
Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 12
Abstract
Abstract:In Poland, sarcoma accounts for about 1% of all malignancies annually about 800 new cases are diagnosed. The most commonly diagnosed primary malignancy of the bone is osteosarcoma. These tumors are more likely to be diagnosed in children and adolescents in males, and rarely in pregnant women. The paper describes the treatment of a 29-year old woman who was diagnosed with osteosarcoma in the second trimester was described. Pregnant women have been qualified for multi-drug chemotherapy according to AP3, which is the primary treatment for this type of sarcoma. From 23 to 34 weeks pregnant she received 4 cycles of cytostatics while monitoring the welfare of the fetus. Pregnancy was terminated by caesarean section at 34 weeks gestation giving birth to a healthy daughter. Surgical removal of the tumor from the chest wall resulted in complete radicalization (R0) of the treatment and continued chemotherapy followed by five further cycles following the same regimen. Because of Hashimoto's disease, two years before pregnancy, he was also monitored for thyroid hormone levels and endocrine monitoring without the need for hormonal substitution. Eighteen months after the treatment of sarcoma, the patient feels well not to have relapses and the baby develops properly. Administering multidrug-resistant chemotherapy in full, due doses of 23 to 32 weeks will not cause any damage to the fetus. And after 18 months from the end of treatment, there is no cure for motherly failure and the baby develops properly. Keywords:pregnant chemotherapy, sarcoma in pregnant women, osteosarcoma and pregnancy.
Authors and Affiliations
Małgorzata Czetwertyńska, Barbara Kozakiewicz
Keywords
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