Chest Pain Without Coronary Artery Obstruction and Calcification in Young Women May Indicate Left Ventricular Diastolic Dysfunction
Journal Title: Heart Research – Open Journal - Year 2017, Vol 4, Issue 3
Abstract
Background: Left ventricular diastolic dysfunction (LVDD) and coronary artery calcification become worse with increasing age. However, it is unclear whether there is a gender difference in patients with chest pain but no obstructive coronary artery disease (CAD). Aim: This study’s aim was to investigate whether gender and age differences existed in the association between LVDD and the coronary artery calcium score (CACS) in patients with chest pain but no obstructive CAD. Methods: We retrospectively studied a total of 705 patients (age 65±13 years; men 342, 49%) who had chest pain, normal LV ejection fraction on echocardiography, and no obstructive CAD on computed tomography (CT) coronary angiography. LVDD was defined by the American Society of Echocardiography recommendation of septal e’<8. Abnormal CACS was defined as CACS of >0. Results: Although, there was a significant difference in LVDD prevalence among patients with normal and abnormal CACS (76.1% vs. 88.9%; p<0.001), in a multiple logistic regression analysis, LVDD was not significantly associated with abnormal CACS. When the patients were divided according to gender and age (decades; 20-29, 30-39, 40-49, 50-59, 60-69, 70-79 years), the proportion of men and women with abnormal CACS increased with age. On the other hand, young women (age 20-39 years) with normal CACS showed a high LVDD prevalence, although older women (age 60-69 years) and young men (age 20-39 years) had a low LVDD prevalence. Conclusions: Young women with chest pain but no obstructive and no calcified CAD, which associated with LVDD. LV diastolic function assessment by echocardiography should be performed in young women with chest pain even with normal CT coronary angiogram.
Authors and Affiliations
Masao Moroi
Keywords
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- EP ID EP557983
- DOI 10.17140/HROJ-4-145
- Views 130
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