CHI3L1 Overexpression In Different Types Of Ovarian Cancer
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Epithelial ovarian cancer contributes to a large proportion of mortality among all cancer in women due to late diagnosis at an advance stage. The present study was done on 40 ovarian cancer patients which include 35 patients wuth epithelial tumor, 3 patients with germ cell tumor, 2 patients with sex chord stromal tumor and 8 healthy controls. Objective was to test the usefulness of CHI3L1 for diagnosis of ovarian cancer at an early stage. CHI3L1 level (80.0-414.2 ng/ml) was significantly higher in ovarian cancer patients as compared control group (24.8-123.4 ng/ml). CHI3L1 level was also tested in different ovarian cancer types, histological subtypes of EOC and in different stage. Plasma levels of CHI3L1 was elevated in all histological sub types as 88% serous tumor patients, 80 % mucinous tumor patients and 60% undifferentiated tumor patients have elevated marker level. With increasing stage, percentage of patients having elevated CHI3L1 value also increased as it was elevated in 67% of patients in early stage whereas 85% of patients in advance stage have elevated CHI3L1 value.
Authors and Affiliations
Geetanjali Yadav, Minakshi Vashist2 , R, , Rajiv Sen3, Ritu Yadav, Nidhi Paliwal5
Keywords
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- EP ID EP390136
- DOI 10.9790/3008-1204052832
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