CHILDHOOD NEPHROTIC SYNDROME -A SINGLE CENTRE EXPERIENCE IN ALTHAWRA CENTRAL HOSPITAL, ALBAIDA-LIBYA DURING 2005-2016
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 12
Abstract
The aim of this study to determine respose to treatment in terms of remission and relapse, related risk factors, type of management and complications of nephrotic syndrome among studied patients. Design: Retrospective, analytical study. Setting: Pediatric nephrology clinic at Althawra Central Teaching Hospital-Albida, Participants/patients: All patients withidiopathic nephrotic syndrome (INS)were evaluated during 2005- 2016. Patients divided into two groups, group I 46 (39%) is non-relapseand group II 72 (62.7%) is relapse group. Group II are sub divided into group A: frequent relapse steriod dependent (FRNS/SDNS)and group B:infrequent relapse nephrotic syndrome(IRNS). Results: Records of 118 children with INS were studied and 74 (62.7%) were boys, male to female ratio 1.7:1. There was no significance difference between group I and group II in the following parameters; age group, sex, family history, initial hypertension and hematuria(p value = >0.05). Mean proteinuria was significantly higher in group II (p 0.001), while mean s. albumin, mean s. cholesterol and mean blood urea did not show any significant difference statistically and p value were (0.022),(0.012),(0.116) respectively. Group B showed significant higher frequency than group A regardingsex(p=0.010), age group 1 and positive family history (p=0.050), both groups were comparable regarding gross hematuria and hypertension (p=0.975). Mean s albumin was significantly low in group A (p = 0.03) but no significance difference between both group regarding mean proteinuria, lipid profile and renal function and the p value for the three variables were (0.015) (0.206), (0.257) respectively. The most common complications were hypocalcemia, cushingoidfacies and obesity(26.5%, 25.4%, 18.6%) respectively, followed by infections (13.5%), hypertension (11.8%), acute kidneyinjury(8.4%), chronic kidney disease (1.7%) and death in onepatient (0.8%). Conclusions: Idioptic nephrotic syndrome is chronic relapsing disease for most steroid-responsive patients especially males between 2 -8 years with different complications of disease and its treartment affecting patient's life.
Authors and Affiliations
Dr. Mabrouka A. M. Bofarraj
Keywords
Related Articles
- EP ID EP646141
- DOI -
- Views 170
- Downloads 0
TREATMENT OF PATIENTS WITH GASTRIC CANCER LIVER METASTASES
Despite of steady decline in the incidence of gastric cancer (GC), for many countries, this pathology remains one of the most important medical and socio-economic problems.[1,2,3,5] Analysis of mortality data in 24 econo...
RETINOBLASTOMA SUSCEPTIBILITY GENE (RB1) POLYMORPHISM AMONG CHILDREN IN CALABAR, NIGERIA
Retinoblastoma is an eye disease causing blindness and death in children. The screening of the RB1 gene in retinoblastoma children, relatives and controls lead to the documentation of more than 900 mutations in different...
LOW-DOSE KETAMINE INFUSION DURING SURGERY DECREASES ACUTE PAIN AFTER ORTHOPEDIC SURGERY. OUR ANESTHETIST-ORTHOPEDIC SURGEON JOINT EXPERIENCE
Background: Pain attitude is various according to type of operative intervention.Some relief methods for pain after surgery are: Pre-emptive analgesics, multimodal analgesics, epidural analgesia, nerve block, patient con...
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF ACRIDINE-SULFONAMIDE CONJUGATES
The present study describes the synthesis and antiproliferative evaluation of several acridine analogues carrying sulfonamide and thiouredoside chain at C-9 position. The key intermediate aminoacridines5 were prepared by...
CLINICAL RESPONSE OF SOFOSBUVIR (GENERIC, SEARLE) BASED TREATMENT OF CHRONIC HEPATITIS C INFECTION: A PAKISTANI REAL LIFE STUDY HOME (HEPATITIS OBSERVATIONAL MANAGEMENT ENVISION)
Background: Globally, Interferon-free direct-acting antiviral therapy has revolutionized treatment for Chronic Hepatitis C (HCV). However, due to the slow regulatory process of DAAs registration in Pakistan and differ th...