Chinese patent medicine for stable angina pectoris: protocol for a systematic review and network meta-analysis
Journal Title: TMR Integrative Medicine - Year 2022, Vol 6, Issue 1
Abstract
Stable angina pectoris is a common condition that affects a wide group of patients with coronary artery diseases. A number of Chinese patent drugs based on classic herbal formulations are available for angina management. A network meta-analysis is proposed to assess the relative efficacy and safety of commonly used drugs for stable angina and generate a clinically meaningful ranking for each important outcome. We composed a list of 24 widely-used oral blood-quickening Chinese patent drugs from literature review and expert consultation. Three English and five Chinese electronic databases will be searched up to July 2021 for randomised clinical trials comparing between drugs on the list or with nitrates or placebo for stable angina. Unpublished data or grey literature will be sought through trial registries and correspondence to the report authors. Two reviewers independently screen literature, extract data and assess clinical and methodological features of included studies. The WinBUGS software will be used to perform network meta-analysis and the Stata 13.0 software to generate graphic demonstrations of the results. Primary outcomes are the incidence of cardiovascular events and changes in angina frequency, duration and intensity. We will use the surface under the cumulative ranking curve and the mean value for the numeric presentation of efficacy and safety ranking probabilities of multiple treatments. Heterogeneity and inconsistency will be assessed using appropriate statistical tests, and subgroup analysis and network meta-regression will be resorted when necessary. The quality of evidence for each outcome will be graded with the web-based GRADEpro GDT.
Authors and Affiliations
Wei Mu, Deng-Feng Kong, Qiang Xu, Xu-Fang Gu, Jie Li, Bao-He Wang, Ge Li, Jin-Hua Si, Rui-Hua Wang, Yu-Hong Huang
Keywords
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- EP ID EP701897
- DOI 10.12032/TMRIM202206001
- Views 88
- Downloads 0
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