CHITOSAN: A BIOCOMPATIBLE POLYMER FOR PHARMACEUTICAL APPLICATIONS IN VARIOUS DOSAGE FORMS
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
Chitosan is a weak cationic polysaccharide composed essentially of β(1→4) linked glucose amine units together with some acetyl glucose amine units. It is obtained by extensive deacetylation of chitin, a polysaccharide common in nature. Chitosan is biocompatible, biodegradable, and non toxic natural polymer that exhibits excellent film forming ability. As a result of its cationic character, chitosan is able to react with polyanions giving rise to polyelectrolyte complexes. Therefore, because of these interesting properties, it has become the subject of numerous scientific reports and patents on the preparation of micro spheres and microcapsules. The techniques employed to microencapsulate with chitoson include, among others, ionotropic gelation, spray drying, emulsion phase separation, simple and complex coacervation, and polymerization of vinyl monomer in the presence of chitosan. The aim of the work is to review some of the more common techniques used and to put forward the results obtained in preparing chitosan-based microcapsules: for taste masking and improving the stability of nutritional oil, the sustained release of drugs, as well as the preparation of chitosan super paramagnetic microcapsules for immobilization of enzymes.
Authors and Affiliations
Pesaramelli Karteek
Keywords
Related Articles
- EP ID EP139619
- DOI -
- Views 92
- Downloads 0
DETERMINATION OF GALLIC ACID IN ACACIA NILOTICA LINN. BY HPTLC
The stem bark of Acacia nilotica is used as a powerful astringent and the decoction is used as gargle for throat troubles and stomatitis.q3 Bark contains several polyphenols such as catechin, epicatechin, dicatechin, que...
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL<br /> THIAZOLOQUINAZOLINE AS NEW CLASS OF H1-ANTIHISTAMINIC AGENT
A series of novel 6,7,8,9 tetra hydro-5H-5-(2'-hydroxy phenyl)-2-(4'-some substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline were synthesized the reaction with appropriate aromatic aldehydes and p –nit...
FORMULATION STUDIES ON CYCLODEXTRIN COMPLEXES OF MELOXICAM
b-Cyclodextrin (b-CD) and HP-b-Cyclodextrin (HP-b-CD) inclusion complexes of meloxicam (M) exhibited higher dissolution rates and dissolution efficiency values than the corresponding uncomplexed drug. The feasibility of...
HEPATOPROTECTIVE EFFECT OF SOLENA AMPLEXICAULIS (TUBER) ON ACUTE CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY
The hepatoprotective activity of methanolic extract of Solena amplexicaulis (SAME) (Lam.) Gandhi (Cucurbitaceae) at doses of 250 mg/kg and 500 mg/kg were evaluated by carbon tetrachloride (CCl4) intoxication in rats. The...
HEPATOPROTECTIVE ACTIVITY OF SILYMARIN FLOATING DRUG DELIVERY SYSTEM AGAINST ANTI TUBERCULOSIS DRUG
A Gastroretentive floating controlled drug delivery system containing Silymarin was prepared in the form of tablets and evaluated for its processing parameters, in vitro release in 0.1 N HCl. Eight formulations were prep...