CHITOSAN AND CHITOSAN-POLYETHYLENIMINE MICROSPHERES PREPARED BY MEMBRANE EMULSIFICATION AND THEIR APPLICATION FOR DRUG DELIVERY SYSTEMS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2017, Vol 0, Issue
Abstract
The aim of this paper was to prepare chitosan microspheres characterised by a narrow dispersion of dimensions, suitable for application for drug delivery systems (DDS). The materials, unmodified as well as functionalised using polyethyleneimine were then used for encapsulation of drug-mimicking dyes. The polymeric beads were prepared by one stage process of membrane emulsification. The encapsulation and then evaluation of the release of an active component was carried out using two cytostatics-mimicking dyes: methyl orange and Congo red. The efficiency of encapsulation changed with a type of microspheres and the type of a dye. The highest sorption towards dyes was revealed by PEI-modified chitosan microspheres. Methyl orange was released with the better efficiency than Congo red from all types of microspheres.
Authors and Affiliations
Joanna Wolska
Keywords
Related Articles
- EP ID EP320806
- DOI 10.15259/PCACD.22.22
- Views 85
- Downloads 0
RHEOLOGICAL PROPERTIES OF CHITOSAN ACETATE BLENDS WITH VINYL POLYMERS
In the present paper the rheological properties of solutions of chitosan acetate (ChA), poly(vinyl alcohol) (PVA), polyacrylamide (PAM) and of ChA/PVA or ChA/PAM mixtures were studied. The measurements were carried out u...
FORMATION AND CHARACTERIZATION OF SUCCINOYL CHITOSAN PARTICLES LOADED WITH WARNERIN
This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervat...
SCREENING OF THE CATALYTIC ACTIVITY OF Pd0 AND Pd2+- SUPPORTED ON CHITOSAN BEADS AND CRYOGELS
Here, we report the results of screening of the catalytic activity of Pd-containing chitosan beads and cryogels in the cross-coupling reaction, hydrogenation of alkenes, nitro-, and carbonyl compounds and the hydrodechlo...
THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX
The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour a...
DEVELOPMENT OF FOOD IMPROVING CALCIUM-ENRICHED BIOACTIVE AGENTS PRODUCED FROM CHITINOUS WASTES GENERATED IN THE PROCESS OF AQUATIC ANIMAL PROCESSING
The CHIZITEL chitin-and-mineral complex is obtained from crustacean wastes. The BAA formula helping to facilitate calcium, phosphorus and magnesium fixation in the human body was found to be the result of this study. Thi...