Cholestasis in acute stroke: An investigation of its prevalence and etiology
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2006, Vol 23, Issue 3
Abstract
OBJECTIVE At the acute phase of cerebrovascular accidents a rise in liver cholestatic enzymes and/or bilirubin are occasionally observed, usually ascribed to co-morbid conditions. This study investigated the frequency and possible etiology of this phenomenon. METHOD Prospective evaluation for post-admission biochemical cholestasis of all patients hospitalized with acute stroke during a 21-month period. RESULTS Of 169 consecutive patients, 18 (10.7%) developed increased levels of serum alkaline phosphatase (SAP) and γ-glutamyltranspeptidase (γ- GT). In 7 (4.1%; 4 males, 3 females; median age 70, range 57-82 years), no cause for cholestasis could be found, and they were further evaluated (group A). They were compared to 21 of the remaining patients without cholestasis, matched for age and sex (group B). Group A patients were in deeper coma than control cases (Glasgow Coma Scale 3.4±0.8 vs 1.9±0.7, P
Authors and Affiliations
N. SEVASTOS, S. SAVVAS, P. RAFAILIDIS, E. MANESIS
Keywords
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