Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 11
Abstract
Background: Stress and increase in free radicals levels are known to alter cognition, learning, memory, and emotional responses. There is a marked impairment of hippocampus-dependent memory and suppression of long-term potentiation in the CA1 region of the hippocampus during stress. Aim and Objective: The aim of this study is to evaluate the hypothesized neuroprotective effect of oral antioxidants and piracetam in chronic restraint stress-induced rats. Materials and Methods: Healthy Wistar rats were divided into 5 groups (n = 6) each. Control group received neither stress nor oral antioxidant. Stress group received chronic restraint stress for 6 h per day for 21 days. Three experimental groups were administered vitamin C (100 mg/kg), beta-carotene (7 mg/kg), and caffeine (8 mg/kg), respectively. Evaluation parameters were measurement of serum nerve growth factor (NGF) using ELISA method. The oxidative stress markers, glutathione peroxidase (GPx), glutathione reductase, and malondialdehyde were measured. Histological analysis of CA1 region of the hippocampus was done to evaluate the structural changes of pyramidal neurons. Results: Vitamin C caused statistically significant (P < 0.001) increase in serum NGF. The results revealed that vitamin C caused statistically significant (P < 0.05) increase in antioxidant enzymes GPx, glutathione reductase. Vitamin C caused increase in neuronal cell size and volume in CA1 pyramidal layer of hippocampus. Conclusion: The findings of study are suggestive of neuroprotection, offered by administration of vitamin C compared to other antioxidants against chronic restraint stress-induced rats. These naturally available dietary vitamins might serve as an adjuvant therapy to avoid progression of brain damage during stress.
Authors and Affiliations
Sangeetha A, Surapaneni Krishna Mohan, Kumaresan M
Keywords
Related Articles
- EP ID EP292098
- DOI 10.5455/njppp.2017.7.0621123062017
- Views 50
- Downloads 0
The attitudes of final year medical and pharmacy students to interprofessional learning in Iraq
Background: Interprofessional learning (IPL) is considered as the gold standard strategy to improve health-care teamwork. The IPL will help the students to improve their knowledge and professional attitudes. The advantag...
Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice
Background: Mimosa pudica is a traditionally used folk medicine to treat various disorders such as bleeding disorders, dysentery, piles, convulsions, rheumatoid arthritis, muscular pain, and snake bite. Aims and Objectiv...
Placenta previa, anemia, care in antenatal, employment score: Development of a scoring system to predict low birth weight in underserved area in Indonesia
Background: Early intervention of low birth weight (LBW) should reduce maternal and fetal morbidity. In underserved areas, with inadequacy of health technologies, it was very important to develop a simple scoring system...
Effect of pranayama on respiratory muscle strength in chronic asthmatics
Background: Pranayama is a breathing technique that produces many systemic and psychological effects in the body, specifically on the respiratory system. It is also an art which controls the life force of breath. Aims an...
Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models
Background: Diabetes mellitus is not only a chronic metabolic disorder but also an inflammatory one. Antidiabetic drugs are required to address both these entities to reduce the micro- and macro-complications...