Chronic Interstitial Nephritis Induced by Deferasirox (Exjade): An Oral Iron-Chelating Agent in a Patient with Thalssemia Major
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
We report on the development of chronic interstitial nephritis induced by Deferasirox (Exjade). The patient is a 40-year-old woman, with history of thalassemia major had developed progressive increase in serum creatinine up to 150 umol/L and proteinuria at 2 g/day over 6 months following 9 years-treatment with 500 mg/daily of Exjade as an oral iron chelating agent. Her kidney biopsy showed chronic interstitial inflammation and fibrosis with 73% secondary global glomerulosclerosis. In conclusion, patients treated with Exjade are at risk of irreversible kidney damage by interstitial inflammation and fibrosis.
Authors and Affiliations
Kamel El-Reshaid, Dalal Al-Bader
Keywords
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- EP ID EP544790
- DOI 10.21276/ijmrp.2017.3.2.060
- Views 70
- Downloads 0
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