CHRONIC MYELOID LEUKEMIA PATIENT WITH ISOLATED CENTRAL NERVOUS SYSTEM BLAST CRISIS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 9
Abstract
The first therapeutic choice in Chronic Myeloid Leukemia (CML) is imatinib mesylate, a potent inhibitor of BCR / ABL tyrosine kinase. The blood brain barrier is poorly penetrated so that therapeutic concentrations in the cerebrospinal fluid (CSF) can hardly be achieved. Extramedullary blast crises of CML involving central nervous system (CNS) is uncommon and usually accompanies systemic relapse. We report a 42 year old male who initially had no excess blasts of the peripheral blood or bone marrow but 2 months later he presented with isolated CNS blast crisis while he is on imatinib 400mg. He was treated successfully using FLAG Ida protocol combined with dasatinib 100 mg and intrathecal chemotherapy. Patient achieved major molecular response and referred for allogeneic bone marrow transplant.
Authors and Affiliations
Dr. Ahmed Mjali
Keywords
Related Articles
- EP ID EP669111
- DOI -
- Views 121
- Downloads 0
SIRT-1 ACTIVATORS –IN DIABETIC NEPHROPATHY
Sirtuin plays important role in renoprotection, SIRT-1 is key when activated by drugs like Resveratrol, Roflumilast, Grape seed, Panax ginseng, Glycyrrhizic acid provided renal protection in diabetic model. SIRT-1 activa...
DEVELOPMENT AND IN VITRO EVALUATION OF POLYSACCHARIDE-BASED SYSTEM FOR INTESTINAL DELIVERY OF AZATHIOPRINE FOR TREATMENT OF GASTRODUODENAL CROHN’S DISEASE, JEJUNOILEITIS AND ILEITIS
Azathioprine is immunosuppressant drug used effectively for treatment of gastroduodenal Crohn’s disease, jejunoileitis and ileitis. The systemic administration of azathioprine is characterized by its slow onset of action...
MEDICAL PRESCRIPTION: ERRORS DETECTED IN NATIONAL HEALTH INSURANCE CENTRAL HOSPITAL OF ASUNCIÓN PARAGUAY
This paper aims to describe errors in medical prescriptions (EMP) issued by various medical professionals and the interventions in the Pharmacy of the Central Hospital of the Social Security Institute (HC-IPS) of Paragua...
QUANTIUM THEORICAL ANALYSIS OF MORINGA AND NITROGENOUS BASES OF DNA AND RNA
Moringa (Mo) is used as traditional medicine in different parts of the world. This work aims to treat by theoretical means and using quantum chemistry to show if the main components of this plant work as it has been trie...
FORMULATION DEVELOPMENT AND EVALUATION OF SKIN CARE EMULGEL FROM NATURAL OILS
This study was aimed to formulate Linseed oil loaded Emulsion (o/w) based gels, by using various concentrations of rose oil and lemon oil as penetration enhancers for transdermal drug delivery. By using response surface...