Circulating Angiogenesis Factors in Patients with Non-Hodgkin’s Lymphoma
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 17
Abstract
Aims: Non-Hodgkin’s lymphoma (NHL) is a heterogeneous group of hematological malignancies. Several angiogenic factors are important in NHL. The objective of this study was to determine plasma levels of various proangiogenic [vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), tumor necrosis factor (TNF-α), transforming growth factor (TGF-β), interleukin (IL-6), IL-8] and antiangiogenic [IL-4, IL-12, interferon gamma (IFN-)] factors in NHL patients and implication of CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone) therapy on these mediators. Study Design: This study was conducted on 100NHL patients recruited from the Oncology Hospital, Menofia University, Egypt. Fifty patients had different doses of CHOP chemotherapy and 50 patients were without treatment. Another 119 healthy blood donors were served as healthy controls. Methodology: Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of these mediators in plasma of NHL patients and normal controls. Results: Several proangiogenic (VEGF, PDGF, IL-8, and TNF-α) (P<.001, P<.01, P<.01, and P<.001) and antiangiogenic (IL-4,IL-12) (P=.05,P<.01) mediators were decreased in NHL patients. In contrast, IL-6, and IFN-) were increased (P<.001). After CHOP treatment, VEGF, and PDGF were significantly increased (P<.001) as compared to NHL without therapy Fig.1. Reduction in IL-8 (P<.01) and TNF-α (P<.001) in untreated NHL patients was continued after CHOP treatment. IL-6 was the only elevated cytokine in NHL patients with (P<.001) or without (P<.001) treatment compared to healthy individuals. Concerning the antiangiogenic mediators, treatment resulted in reduction in the secretion level of IFN-) (P<.001) and IL-12 (P<.001). Although CHOP treatment required more than 8 doses to be able to down regulate proangiogenic (VEGF,PDGF, IL-8,TNF-α and IL-6) and elevate antiangiogenic (IL-4,IL-12,IFN-) mediators, changes were statistically insignificant. Conclusion: Collectively, our study stressed on the importance of having an angiogenic profile of NHL patients under treatment which could be used to monitor the efficacy of cancer therapy particularly in therapy with antiangiogenic drugs. Further studies are required to confirm these results.
Authors and Affiliations
Roba M. Talaat, Naser Abdel-Bary, Rawia F. Sadek, Eman A. El-Maadawy, Amal M. Abdel-Aziz
Keywords
Related Articles
- EP ID EP349495
- DOI 10.9734/BJMMR/2014/8582
- Views 46
- Downloads 0
Concurrent Prediabetes and Prehypertension in a Rural Community in South East Nigeria
Aim: To determine the prevalence of concurrent prediabetes and prehypertension among apparently healthy adults in Ihuokpara, a rural community, South East Nigeria. Study Design: The study was cross-sectional. Place and...
Dermatologic Effects and Management of Urine and Feces on Infant and Adult Skin
The effect of urine and feces on the skin is a contributing factor to the development of incontinent and diaper dermatitis. The objective of this research was to evaluate skin effects of a given urine or fecal sample on...
Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Menoufia University Hospitals, Egypt
Aims: Detect the incidence of urinary tract infection caused by candida species and to determine their antifungal susceptibility, biofilm formation and its minimal biofilm inhibitory concentration. In addition, detect th...
Reflective Learning Experience in Primary Care Medicine Posting: A Potential Qualitative Study
Purpose: The purpose of this study is to determine the effects of reflection on learning during family medicine posting, to introduce a reflective writing exercise into an undergraduate medical curriculum, including thei...
Prevalence and Determinants of Poor Sleep Quality among Myanmar Migrant Workers in Malaysia: A Cross-sectional Study
Background: Sleep quality is an important determinant of health; so much so that the socio-economic and healthcare burden of poor sleep quality is alarming. In Malaysia, there is a shortage of sleep-quality studies condu...