Circulating Endothelial Cells and Cardiovascular Risk in Chronic Kidney Disease and Hemodialysis Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 9
Abstract
Chronic kidney disease is a potent risk factor for cardiovascular disease and it remains the leading cause of morbidity and mortality in patients with chronic kidney disease. As renal function declines, there are a host of abnormalitiesthat develop, including changes in coagulation, fibrinolysis, lipids, endothelial dysfunction, and many other factors that have been related to cardiovascular disease. This work was conducted with the aim to study circulating endothelial cells count in chronic kidney disease and hemodilaysis patients and correlate this to other markers of cardiovascular risk in this population. The study included 50 subjects classified as follows: Group I included 20 patients with chronic kidney disease not yet on dialysis, group II included 20 patients on maintenance hemodialysis and 10 age and sex matched individual used as a control (group III). All included individual were subjected to complete blood count, renal function tests, estimation of glomerular filtration rate by Modification of Diet in Renal Disease formula for non –dialysis patients, complete lipid profile, high sensitive C-reactive protein, and erythrocyte sedimentation rate, and detection of circulating endothelial cells count using flow cytometry. The study showed increased count of circulating endothelial cells and high sensitive C-reactive protein in both patients groups than the control and it was higher in patients on dialysis than those on conservative treatment. There was a statistically positive correlation between erythrocyte sedimentation rate, high sensitive C-reactive protein, Triglycerides and circulating endothelial cells in the three groups. So, detection of circulating endothelial cells count might offer a mean for recognizing chronic kidney disease patients at risk of cardiovascular events
Authors and Affiliations
A Naenaa Yasser
Keywords
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