Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome
Journal Title: Journal of Clinical and Translational Research - Year 2019, Vol 5, Issue 1
Abstract
Background: Given high on-treatment mortality in heart failure (HF), identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues. Circulating extracellular RNAs (ex-RNAs) regulate important biological processes and are emerging as biomarkers of disease, but less is known about their role in the acute setting, particularly in the setting of HF. Methods: We examined the ex-RNA profiles of 296 acute coronary syndrome (ACS) survivors enrolled in the Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education Cohort. We measured 374 ex-RNAs selected a priori, based on previous findings from a large population study. We employed a two-step, mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes (left ventricular [LV] ejection fraction, LV mass, LV end-diastolic volume, left atrial [LA] dimension, and LA volume index) then tested relations of these ex-RNAs with prevalent HF (N=31, 10.5%). We performed further bioinformatics analysis of microRNA (miRNAs) predicted targets’ genes ontology categories and molecular pathways. Results: We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF. Of these 44 exRNAs, miR-29-3p, miR-584-5p, and miR-1247-5p were also associated with prevalent HF. The three microRNAs were implicated in the regulation p53 and transforming growth factor-β signaling pathways and predicted to be involved in cardiac fibrosis and cell death; miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation. Conclusions: Among ACS survivors, we observed that miR-29-3p, miR-584-5p, and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF. Relevance for Patients: miR-29c-3p, miR-584-5p, and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF.
Authors and Affiliations
Khanh-Van Tran, Kahraman Tanriverdi, Gerard P. Aurigemma, Darleen Lessard, Mayank Sardana, Matthew Parker,Amir Shaikh, Matthew Gottbrecht, Zachary Milstone, Selim Tanriverdi, Olga Vitseva, John F. Keaney, Catarina I. Kiefe, David D. McManus, Jane E. Freedman
Keywords
Related Articles
- EP ID EP678745
- DOI -
- Views 231
- Downloads 0
The rush to novelty and high expectations in surgery: the case of ALPPS
In the editorial that accompanied the publication of the inaugural ALPPS paper (associating liver partition and portal vein ligation for staged hepatectomy), ALPPS was termed “the biggest technical innovation in liver su...
Health IT and digital health: The future of health technology is diverse
When discussing the future of technologies in healthcare, one must make a clear distinction between issues regarding IT (Information technology) and digital health. The two areas are often intermingled while their nature...
FITC-linked Fibrin-Binding Peptide and real-time live confocal microscopy as a novel tool to visualize fibrin(ogen) in coagulation
Background and Aim: Although fibrinogen has been established as a key player in the process of coagulation, many questions about the role of fibrinogen under specific conditions remain. Confocal microscopic assessment of...
Acellular porcine heart matrices: whole organ decellularization with 3D-bioscaffold & vascular preservation
Regenerative medicine, particularly decellularization-recellularization methods via whole-organ tissue engineering, has been increasingly studied due to the growing donor organ shortage. Though numerous decellularization...
Limitations of Quantitative Blush Evaluator (QuBE) as myocardial perfusion assessment method on digital coronary angiograms
Background and Aim: Quantitative Blush Evaluator (QuBE) is a software application that allows quantifying myocardial perfusion in coronary angiograms after a percutaneous coronary intervention. QuBE has some limitations...