Circulating Lipocalin-2 Levels Are Associated With Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels In Type 2 Diabetic Patients
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 5
Abstract
Purpose: Diabetes mellitus is associated with atherosclerotic and cardiovascular diseases. Our aim was to investigate the levels of lipocalin-2 (LCN-2) and soluble Lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1) levels in both diabetics and prediabetic with comparison to non-diabetic subjects. We also examined the association of LCN-2 with sLOX-1 and albuminuria Methods: One hundred forty-two subjects with type 2 diabetes mellitus, 32 prediabetic subjects, 58 non-diabetic controls were consecutively enrolled in this study. LCN-2 and sLOX-1 levels were measured with ELISA assays. Results: LCN-2 levels didn’t show significant difference between diabetics, prediabetic and control groups (p = 0.864). sLOX-1 levels were significantly lower in diabetic group (2.53 ng/mL, median) compared with prediabetic (2.84 ng/mL, median; p = 0.041) and control groups (3.00 ng/mL, median; p = 0.001). Multiple linear regression analysis showed that urinary albumin excretion and sLOX- 1 were independently associated with LCN-2. When logistic regression analysis was performed LCN-2 was independent factor determining albuminuria (p = 0.021; OR, 1.001; (1.000-1.001) 95% CI). Conclusion: Our study provides the first clinical evidence demonstrating serum LCN-2 concentrations are independently associated with sLOX-1 levels which were found to be lower in type 2 diabetics unexpectedly. LCN-2 was also associated with albuminuria.
Authors and Affiliations
Banu Sarer Yurekli, Gokcen Unal Kocabas, Cem Mirili, Asli Suner, Murat Aksit, Ismail Yurekli, Nilufer Ozdemir Kutbay, Ilgin Yildirim Simsir, Giray Bozkaya
Keywords
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- EP ID EP413637
- DOI 10.15226/2374-6890/5/5/001116
- Views 73
- Downloads 0
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