Circulating Visfatin And Proinflammatory Cytokine Levels In Nonalcoholic Fatty Liver Disease
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2014, Vol 6, Issue 8
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, ranges from simple steatosis to nonalcoholic steatohepatitis, fibrosis and cirrhosis. Several adipocytokines such as leptin and adiponectin have been implicated in the pathogenesis of NAFLD. However, there are only few data concerning visfatin. Objective: This study is aimed to evaluate the relationship among circulating visfatin and proinflammatory cytokines in NAFLD. Material and Methods: The study includes 64 NAFLD and 22 healthy controls with no evidence of liver disease were included. NAFLD was clinically diagnosed on the basis of USG and ALT levels. Serum Visfatin levels were measured using ELISA kit, tumor necrosis factor-α, interleukin-6 and interlukin-8 were measured by Flow Cytometer (BD FACS Array II). Fasting blood glucose, lipid profile and liver enzyme were measured using auto analyzer (Randox). The data were analyzed by SPSS 13.0 version and P value˂0.05 were consider significant. Results: Serum visfatin concentration in the NAFLD group (6.38±5.18ng/ml) was significantly lower than in controls (24.62±15.14ng/ml) (P<0.001). There was no correlation between visfatin and anthropometric parameters, TNF-α, IL-6, and IL-8. Conclusion: The results of this study indicate that increased levels of proinflammatory cytokines TNF-α, IL-6, IL-8 and decreased levels of Visfatin are independently associated with NAFLD.
Authors and Affiliations
Sadik Ali Mohammad, Shaik Sarfaraz Nawaz, Imran Ahmed Siddiqui, Sasikala, M. , Rathindara Mohan Mukarjee, Nagaraj Rao Nageshwar Reddy D
Keywords
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