cis-Antisense RNA and Transcriptional Interference: Coupled Layers of Gene Regulation
Journal Title: Journal of Gene Therapy - Year 2013, Vol 1, Issue 1
Abstract
Antisense transcription is omnipresent occurring broadly in most living organisms. Growing evidence suggests the presence of noncoding cis-antisense RNA’s that can silence gene expression. Recent studies also indicate the role of transcriptional interference in regulating expression of neighboring genes arranged in convergent orientation. A combination of transcriptional interference and cis-antisense RNA interaction has the potential to add multiple-levels of regulation which can allow such a system to have a tunable and complex higher-order system response to environmental stimuli. This presents an important insight into the functional role of antisense transcription.
Authors and Affiliations
Anushree Chatterjee
Keywords
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- EP ID EP246298
- DOI 10.13188/2381-3326.1000004
- Views 111
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