Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study
Journal Title: Journal of Case Reports and Studies - Year 2018, Vol 6, Issue 4
Abstract
Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy. This was proven by a two-dimensional echocardiography with an ejection fraction dropping from 65% to 35%. In our perspective, cardiomyopathy could be related to cisplatin-gemcitabine, which is a rare but potential risk factor for developing cardiomyopathy especially if the patient has pre-existing comorbidities that may potentiate toxicity. An instant discontinuation with close monitoring is needed. Furthermore, we suggest considering other options of chemotherapy for patients if they develop cardiac adverse events.
Authors and Affiliations
Dawoud RA
Keywords
Related Articles
- EP ID EP584876
- DOI 10.15744/2348-9820.6.405
- Views 101
- Downloads 0
Lethal Dance with Dialysis – A Case of Silent Long QT Syndrome
Fatal arrhythmia is the leading cause of mortality in chronic haemodialysis patients. Long QT syndrome is responsible for polymorphic ventricular tachycardia known as Torsade de Pointes. Classically, long QT syndromes we...
Atypical Femur Fracture Nonunion in a Patient with Osteogenesis Imperfecta
Case: Here, we present a 43-year-old male with osteogenesis imperfecta (OI) with previously placed intramedullary growing rods that sustained an atypical femur fracture (AFF) following long-term bisphosphonate use. He ad...
Spontaneous CSF Rhinorrhea as Clinical Symptom of an Idiopathic Temporal Encephalocele in a 64 Year Old Man
A rare case of idiopathic temporomesial encephalocele in a 64 years old female is presented. The clinical symptoms of this adult patient were spontaneous rhinorrhea and headaches. A temporomesial encephalocele could be d...
Acquired Factor XII Deficiency in a Patient with Schizophrenia
We report a 50-year-old man who presented schizophrenia and an abnormal coagulation profile indicative of an inhibitor. Clinical experiments demonstrated prolonged partial thromboplastin time along with acquired factor X...
Neuropsycological Function, Insight, and Treatment Adherence among Patients with Schizophrenia
Introduction: Research has suggested that poor insight in patients with schizophrenia is associated with poorer treatment compliance. One factor ontributing to poor insight may be neurocognitive deficits. Objectives: The...