CKMB Role as Cardiac Toxicity Prognostic Marker in Acute Organophosphorus Poisoning
Journal Title: Journal of Cardiovascular Medicine and Surgery - Year 2018, Vol 4, Issue 2
Abstract
Introduction: Acute Organ phosphorous compound (OPC) poisoning is an important indication for emergency admission in most hospitals throughout India. Cardiac complications that often accompany poisoning with these compounds may be serious and are often fatal. These complications are preventable, if they are recognized early and treated adequately. Objectives of the study is to assess the cardiac toxicity in Organ phosphorous compound poisoning and to associate electrocardiogram changes and CKMB levels among Organ phosphorous compound poisoning patients. Materials and methods: A hospital based observational study among 37 adult patients who presented to emergency department of tertiary care centre with Organ phosphorous Compound Poisoning. Informed consent and institutional ethical clearance was obtained before study. Electrocardiography (ECG) was done, plasma Pseudocholiesterase levels and CKMB levels were measured. Outcome measures considered were recovery or death. Post mortem Histopathological findings of cardia were recorded. Results: In the study 37 adult patients with OP poisoning were included. Mortality rate was 8.1% (3). Significant association was observed between outcome and CKMB levels. All the patients who mortality had significantly higher levels of CKMB compared to others. There was also significant association between outcome and ECG changes. Out of 3 patients who died 2 had abnormal ECG changes. All the patients who died had consumed chlorpyriphos compound. Histopathological findings of heart in all the subjects who had mortality showed myocardial interstitial edema, vascular congestion and Patchy interstitial inflammation and one showed patchy myocarditis with other findings.Conclusion: Patients with organophorphorus compound poisoning should beevaluated for electrocardiogram along with CKMB which helps in predicting cardiac toxicity and can be considered as a surrogate prognostic marker.
Authors and Affiliations
Ravishankar M. S.
Keywords
Related Articles
- EP ID EP563618
- DOI 10.21088/jcms.2454.7123.4218.2
- Views 129
- Downloads 0
Renal Artery Stenosis Complicated by Thoracic Aortic Dissection: A Case Report
Renal artery stenosis is an uncommon presentation of secondary hypertension. We present a case of bilateral renal artery stenosis complicated by thoracic aortic dissection. The patient underwent successful thoracic endov...
Assessing Rv Function in Patients with Corpulmonale by Using Newer Echocardiographic Parameters
Aim: In the present study was investigate that the Newer Echocardiographic parameters in assessing right Ventricular and left ventricular function in patients with Cor Pulmonale. Cor Pulmonale is defined as hypertrophy o...
Epidemiology and Management of Junctional Ectopic Tachycardia after Cardiac Surgery: A Review
Junctional ectopic tachycardia is a form of supraventricular tachyarrhythmia which is very common after cardiac surgery. It is more often detected in pediatric age group. The development of JET is because of multiple ris...
Study to Compare Classical Herniotomy versus Newer Method of Non Ligation Herniotomy: Our Institutional Experience
Objective: To compare outcome in terms of recurrence and complications in children operated by classical method of herniotmy with sac ligation versus newer method of non ligation of sac. Material and method: 100 children...
Study on Clinical Profile and risk factors of Coronary Artery Disease in Indian Women
Background: Coronary artery disease (CAD) is a common cause of death or disability in men and women, but CAD manifests differently in women. Besides traditional risk factors, diabetes and hypertriglyceridemia carry great...