CKMB Role as Cardiac Toxicity Prognostic Marker in Acute Organophosphorus Poisoning
Journal Title: Journal of Cardiovascular Medicine and Surgery - Year 2018, Vol 4, Issue 2
Abstract
Introduction: Acute Organ phosphorous compound (OPC) poisoning is an important indication for emergency admission in most hospitals throughout India. Cardiac complications that often accompany poisoning with these compounds may be serious and are often fatal. These complications are preventable, if they are recognized early and treated adequately. Objectives of the study is to assess the cardiac toxicity in Organ phosphorous compound poisoning and to associate electrocardiogram changes and CKMB levels among Organ phosphorous compound poisoning patients. Materials and methods: A hospital based observational study among 37 adult patients who presented to emergency department of tertiary care centre with Organ phosphorous Compound Poisoning. Informed consent and institutional ethical clearance was obtained before study. Electrocardiography (ECG) was done, plasma Pseudocholiesterase levels and CKMB levels were measured. Outcome measures considered were recovery or death. Post mortem Histopathological findings of cardia were recorded. Results: In the study 37 adult patients with OP poisoning were included. Mortality rate was 8.1% (3). Significant association was observed between outcome and CKMB levels. All the patients who mortality had significantly higher levels of CKMB compared to others. There was also significant association between outcome and ECG changes. Out of 3 patients who died 2 had abnormal ECG changes. All the patients who died had consumed chlorpyriphos compound. Histopathological findings of heart in all the subjects who had mortality showed myocardial interstitial edema, vascular congestion and Patchy interstitial inflammation and one showed patchy myocarditis with other findings.Conclusion: Patients with organophorphorus compound poisoning should beevaluated for electrocardiogram along with CKMB which helps in predicting cardiac toxicity and can be considered as a surrogate prognostic marker.
Authors and Affiliations
Ravishankar M. S.
Keywords
Related Articles
- EP ID EP563618
- DOI 10.21088/jcms.2454.7123.4218.2
- Views 121
- Downloads 0
Cardiovascular Disease Risk Factors and Socioeconomic Status: A Cross Sectional Study of Children and Adolescents from Western India
Background: Socio-economic status isknown to possess an inverse relationship with cardiovascular disease risk. Aims: We aimed to investigate the prevalence of cardiovascular disease risk factors in children and adolescen...
Management of Tracheobronchial Foreign Bodies in Adults and Children: 117 Cases
Objective:Tracheobronchial foreign body is commonly seen in children compared to adults. Accidental aspiration is the commonest cause .If not treated by timely intervention, leads to death and severe respiratory complica...
Cardiac Surgery Procedures in a Rural Tertiary Care Teaching Hospital: Our Experience
Background: A successful cardiac surgery centre requires a lot of resources, skilled professionals, ancillary services and a defined patient population. Such centres are functional in super-specialty hospitals of big cit...
Comparison of TIMI, Pursuit, Grace Risk Scores in Indians with NSTEMI: A Prospective Cohort Study
Background: Patients with non ST elevation myocardial infarction (NSTEMI) are a very heterogenous population, with varying risks of early and longterm adverse events. Early risk stratification at admission seems to be es...
Study of Clinico-Etiological Profile of Patients with in-Stent Restenosis in Population of Western India
Background: Drug-eluting stents (DES) represent a significant improvement in the treatment of coronary artery disease as they decrease restenosis rates by approximately 50% compared with bare-metal stents. The study aime...