Classical type of sporadic Creutzfeldt — Jakob disease (clinical case)
Journal Title: Український неврологічний журнал - Year 2019, Vol 0, Issue 1
Abstract
The article describes in detail the clinical case of a patient who was hospitalized in the Department of Neurology N 1 of the Dnipropetrovsk Regional Clinical Hospital n. a. I. I. Mechnikov. Her diagnosis was verified as one of the rare diseases of the central nervous system, Creutzfeldt — Jakob disease. It is a prion neurodegenerative disease, also known as transmissible spongiform encephalopathy, that affects animals as well as people. Rapidly progressive dementia, motor disorders and lethal outcome are typical for the disease. The literature review is suggested in the paper concerning prion brain disease, prion proteins, their effect on human organism as triggers of some diseases. The paper outlines some information about disease epidemiology, that occurs more often than other prion diseases, modern theories on pathogenesis of these diseases, classification, detailed picture of clinical case of Creutzfeldt‑Jakob disease. We identified methods of additional investigation which can be used for the diagnosis of the disease and changes that may arise due to these methods. Particular attention is paid to liquor investigation to identify separate proteins that can be used as markers of prion brain impairment and their role in diagnostics of the disease. By the example of the case we have demonstrated the typical progress, clinics and application of mentioned methods that provides us with verification of the disease when patient is alive.
Authors and Affiliations
S. O. Makarov, Yu. V. Bukreieva, V. I. Pashkovskyi, O. V. Pogorielov
Keywords
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- EP ID EP594462
- DOI 10.30978/UNJ2019-1-47
- Views 91
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