Cleidocranial dysplasia. A molecular and clinical review
Journal Title: International Dental Research - Year 2018, Vol 8, Issue 1
Abstract
Cleidocranial dysplasia (CCD) is a rare autosomal dominant disorder characterized by skeletal and dental abnormalities primarily, short stature, aplasia or hypoplasia of clavicles, open fontanelles and supernumerary teeth. Heterozygous mutations of the runt related transcription factor 2 (RUNX2) gene have been found in approximately 60-70% of cases leaving a large number of cases with no defined genetic cause which led us to delve into molecular mechanisms underlying CCD and thus to detect potential target genes to be explored in these patients. In this review we also highlight very broadly the phenotypic characteristics of previously reported patients with CCD. How to cite this article: Avendaño A, Cammarata-Scalisi F, Rizal MF, Budiardjo SB, Suharsini M, Fauziah E, Grande NM, Fortunato L, Plotino G, Yavuz I, Callea M. Cleidocranial dysplasia. A molecular and clinical review. Int Dent Res 2018;8(1):35-38.
Authors and Affiliations
Andrea Avendaño, Francisco Cammarata-Scalisi, Mochamad Fahlevi Rizal, Sarworini Bagio Budiardjo, Margaretha Suharsini, Eva Fauziah, Nicola Maria Grande, Leonzio Fortunato, Gianluca Plotino, İzzet Yavuz, Michele Callea
Keywords
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- EP ID EP369895
- DOI 10.5577/intdentres.2018.vol8.no1.6
- Views 92
- Downloads 0
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