Clenbuterol enhances the production of kynurenic acid in brain cortical slices and glial cultures.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 4
Abstract
The effect of a beta(2)-adrenergic agonist, clenbuterol on the production of a glutamate receptor antagonist, kynurenic acid was studied in vitro. Clenbuterol enhanced the production of kynurenic acid in brain cortical slices (0.1-1.0 mM) and in glial cultures (1-50 muM). Timolol, a non-selective beta-adrenergic antagonist prevented this effect. The presented data indicate a novel mechanism of action of beta(2)-adrenoceptor agonists and suggest that an increased formation of the endogenous glutamate receptor antagonist, kynurenic acid could partially contribute to their neuroprotective activity.
Authors and Affiliations
Elzbieta Luchowska, Renata Kloc, Sebastian Wnuk, Bartosz Olajossy, Marian Wielosz, Ewa Urbańska
Keywords
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