CLIMATE CHANGE, POLLUTION, TROPICAL SEASON, HIV-POSITIVE, HIVNEGATIVE AND HIGH FREQUENCY OF HYPOVITAMINOSIS D IN PATIENTS FROM KINSHASA, DRC
Journal Title: GJRA-Global Journal For Research Analysis - Year 2019, Vol 8, Issue 10
Abstract
Background: The main source of vitamin D from the human skin and synthetized by violets B rays emitted by the sun. Environmental factors such us season, climate change, diets, and pollution, are therefore likely to inuence the levels on vitamin D. Furthermore, High frequency of vitamin D deciency is now observed among HIVinfected patients. There is no published data about HIV and Vitamin D despite few scientic articles on HIV and vitamin D status reported by other African countries. Objective: This study sought to determine specically increased prevalence of vitamin D deciency and environmental factors associated with HIV-positive compared to HIV-negative. Methods: Patients followed in Kinshasa hospitals, DRC, where evaluated between the October 2015 and November 2017 period. Serum levels of vitamin D were measured in adult HIV-positives and HIV-negatives during the dry season and the rainy season in the context of climate change and pollution of the megacity of Kinshasa. Results: Five hundred and six patients were enrolled. The prevalence of moderate (≤29 and ≥20 ng/mL) and severe (<20 ng/mL) 25-OH vitamin D deciency was12% (n=64) and 54,6% (n=273) respectively, 34,4 %had normal status. 62,4% (n=316) and 4,2% (n= 21) of patients with deciency (<30 ng/ml) 25-OH vitamin D were HIV-positive and HIV-negative respectively. Water pollution, air pollution, dry season, and cold season La Niña we resignicantly associated with 25-OH vitamin D deciency (P < 0.0001 and <0,05, respectively). Conclusion: Overall, vitamin D deciency was very high whereas vitamin D deciency was epidemic among HIV-positives in comparison with HIV-negatives. Dry season and La Niña season /climate change-variability related to ultraviolet light and oxidative stress-ecotoxicity related pollution might be considered in the prevention and the treatment of HIV-infection in Kinshasa, DRC, Central Africa.
Authors and Affiliations
Mandina Ndona Madone, Longo-mbenza Benjamin, Renzaho Andre, Lepira Mbompeka François, Makulo Rissassi Jr, Wumba-di-mosi Roger, Ngatu Roger, Apalata Teke Ruphin, Mambueni Thamba Christophe, Mbula Mambimbi Marcel, Situakibanza Nanituma Hippolyte
Keywords
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