Clinical and Etiological Study on Chronic Liver Diseases
Journal Title: ​International Journal of Contemporary Medicine surgery and Radiology - Year 2018, Vol 3, Issue 2
Abstract
Introduction: Chronic liver disease (CLD) with its different aetilogy and presentation is a very common cause of hospital admission in tropical country. This study on CLD includes the diagnosis of aetiology and examination of clinical features as well as detection of associated disease and complications. Aim of the study was to detect the aetiological factors of CLD in and around Calcutta and to study clinical, biochemical, ultrasonographic, endoscopic and histopathological features of different CLD. Material and Methods: This was an observational study conducted on consecutive 35 patients with CLD attending OPD as well as inpatients in CSTM at the School of Tropical Medicine, Kolkata within one year period. In our single centre, prospective, observational study, 35 consecutive patients with CLD were included. Chronic liver disease (CLD) was diagnosed on the basis of clinical findings, laboratory investigations, ultrasonographic and upper GI endoscopic study. Results: Fatigue was the commonest symptom (85.71%). Majority of patients (70%) presented with hepato-splenomegaly with or without jaundice (42.86%). About half of the patients presented with ascites. About 1/3rd of the patients had history of alcoholism or blood transfusion. Raised SGPT was the commonest (83.09%) and most reliable marker of chronic hepatitis. Ultrasonography and upper gastrointestinal endoscopy both helped in the diagnosis of portal hypertension (42.85%). Needle liver biopsy could be done in 11 cases only. Chronic active and chronic persistant hepatitis were found in 3 cases each and 2 idiopathic portal hypertension/ NCPF (non cirrhotic portal fibrosis) diagnosed in 1 case. Liver biopsy was helpful in diagnosing rare causes of hepatomegaly like amyloidosis (1 case) and chronic granulomatous hepatitis (2 cases) in our study. Conclusion: From our study it can be concluded that clinic-aetiological spectrum of CLD can be devided into five major groups – chronic hepatitis, non cirrhotic portal fibrosis, space occupying lesions, metabolic liver disease and chronic granulomatous hepatitis.
Authors and Affiliations
Sudeshna Mallik, Kumkum Sarkar, Mehebubar Rahman, Soumendra Nath Haldar
Keywords
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- EP ID EP424463
- DOI 10.21276/ijcmsr.2018.3.2.19
- Views 103
- Downloads 0
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