Clinical and genetic association of insulin growth factor-2 gene in diabetes mellitus among south Indian population
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 5
Abstract
Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, abnormally elevated hepatic glucose production, and reduced glucose-stimulated insulin secretion. Objective: The aim of this study was to determine the possible association of single-nucleotide polymorphisms located in insulin growth factor-2 (IGF-2) gene on diabetes mellitus. Material and Methods: This case-control study assessed 100 T2DM patients and 100 controls. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism technique. Results: The mean age of the T2DM patients was 61.7 ± 8.8 years with a mean body mass index of 24.0 ± 3.3 kg/m2 . There was a significant difference in the levels of total cholesterol, high-density lipoprotein-C, and triglycerides between the T2DM patients and controls (P < 0.05) while as very low (VLDL) was not associated. Conclusion: We hypothesized that IGF-2 gene was associated with T2DM patients when compared to controls. Both the alleles were significantly associated (P = 0.005). IGF-2 Apa1 can be used as a biomarker for identifying individuals at a high risk of developing T2DM.
Authors and Affiliations
Syed Mudassir Hussaini, Wasey Ali Yadullahi Mir, Mohammed Abdul Tawwab, Adil Wajid
Keywords
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- EP ID EP316257
- DOI 10.5455/ijmsph.2017.1165921122016
- Views 64
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