Clinical and hemodynamic aspects of hepatic and extrahepatic portal hypertension
Journal Title: Гастроентерологія - Year 2018, Vol 52, Issue 1
Abstract
Background. Significant variability of the quantitative indices of portal blood flow in chronic hepatitis, cirrhosis, chronic heart failure, Budd-Chiari disease confirms the need for further search for clinical and hemodynamic features in various forms of portal hypertension (PH). The purpose was to determine the relationship between dopplerographic indices of the portal system, clinical data and the main markers of cytolytic, cholestatic and mesenchymal-inflammatory syndromes in patients with hepatic and extrahepatic PH. Materials and methods. The study included 205 patients with PH and 35 patients without PH who underwent examination and treatment in the gastroenterology department of the Mykolaiv Regional Clinical Hospital. All patients underwent clinical examination, dopplerography of the portal system vessels, and biochemical blood test. Results. In patients with hepatic PН, the greatest changes in the dopplerographic indices of both venous and arterial blood flow were observed simultaneously with a significant degree of cytolysis and cholestasis markers, and the revealed reliable correlation indicates their associative character. A characteristic feature of extrahepatic hypertension was the absence of signs of liver failure or their lesser severity, and no parallelism was found between biochemical and hemodynamic parameters in this form of PН.
Authors and Affiliations
Yu. M. Stepanov, M. V. Chaliy
Keywords
Related Articles
- EP ID EP290782
- DOI 10.22141/2308-2097.52.1.2018.130773
- Views 74
- Downloads 0
Place of phosphatidylcholine in the treatment of inflammatory bowel disease
In the pathogenesis of most diseases of the intestine, inflammation is important, and, often, critical. Its pathogenetic role in the inflammatory bowel disease was studied broadly and comprehensively. In recent years, re...
Hemodynamic Changes in Patients with Chronic Pancreatitis on the Background of Coronary Heart Disease
The analysis of the survey results in 120 patients with chronic pancreatitis and coronary heart disease was conducted. Along with the standard examination, these patients underwent Doppler imaging of the abdominal aorta...
Сomparative Study of Progepar Efficacy in Patients with Non-Alcoholic Steatohepatitis
Non-alcoholic fatty liver disease is one of the most common pathologies of the liver in developed countries. On the average, its prevalence reaches 20 %. In some patients, non-alcoholic fatty liver disease occurs with in...
Immunomorphological Features of Changes of the Local Gastric Mucosal Homeostasis in Chronic HP-Associated Gastritis in Children after Eradication Therapy
The article deals with the results of standard morphological, immunohistochemical study of gastric mucosa biopsy specimens and beta-defensin-2 production in children with chronic HP-associated gastritis taking into accou...
Diagnostics and Correction of Indigestion in a Practice of Family Physician
The results of the study of air-ions in 310 patients with combined pathology of digestive organs are considered in this article. The data about a new non-invasive method of the diagnostics and individual integrated treat...