Clinical and laboratory profile of non-Hodgkin's lymphoma at SKIMS
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 1
Abstract
BACKGROUND: Non-Hodgkin's lymphoma is one of the most commonly occurring haematologic cancer among adults. The majority of NHL cases arise in lymph nodes, but primary extranodal disease now accounts for 20-30% of all cases. OBJECTIVE: To define clinical and laboratory profile of NHL patients, distribution of various subtypes, stage, prognosis, treatment modalities, and survival patterns. METHODS: NHL diagnosis was based on biopsy, subtyping on immunohistochemistry. All patients were analyzed for clinical presentation, type of treatment, stage, WHO class. Staging workup included lab parameters, bone marrow aspiration and biopsy, CECT, PET. Prognostication of patients was done by IPI score, or FLIPI-1(follicular), MCLIPI(mantle cell). RESULTS: Age of the subjects ranged from 4 to 91 years with mean (±SD) of 49.27±18.75 years (Median, 53). Paediatric lymphoma (≤19 years) comprised 8.5% of the total. Lymphadenopathy is the commonest presenting complaint(44.1%). DLBCL is the most common (63.2%) subtype followed by follicular (7.2%), mantle cell (5.2%) NHL. CONCLUSIONS: There was no significant association of smoking with NHL. Farming showed significant correlation with NHL. B symptoms, extranodal disease,T cell lymphoma, were less in magnitude as compared to other Indian studies. T cell lymphoblastic lymphoma was the predominant subtype in paediatric patients. Stage I was the most common followed by stage III. A higher proportion of patients received treatment and less patients failed to complete treatment despite low socioeconomic background and low literacy.
Authors and Affiliations
Ulfat Ara Wani, Sheikh Aejaz Aziz, Gull Mohd. Bhat
Keywords
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