Clinical and molecular characteristics of influenza outbreak in two military bases in Tumbes, Peru 2007
Journal Title: Revista Peruana de Medicina Experimental y Salud Publica - Year 2008, Vol 25, Issue 1
Abstract
[b][i]Objective. [/i][/b]To describe an Influenza outbreak in two military bases in Tumbes, department located in northern Peru. [b][i]Material and methods. [/i][/b]In patients within 5 days of symptoms the Ministry of Health case definition of Influenza-like illness was used. Nasal swabs were taken for Rapid Influenza Test (RIT) and throat swab for viral isolation, three cell lines (MDCK, VERO, LLCMK2) were used. For Influenza B genotypification we made a partial sequencing of hemaglutinine region of 898 pair bases, having 2007 vaccine strain B/Florida/4/2006 as a model. For Influenza A genotypification we analysed 958 pair bases, having 2007 vaccine strain A/Brisbane/10/2007 (H3N2) as a model. [b][i]Results.[/i][/b] We took 124 samples, 20 from military base (MB) # 1 and 104 from MB # 2. RIT promptly identified 41 positive cases: Flu B: 27, Flu A: 02, Flu: 12, with 62% of sensibility and specificity 100%. Finally, 66 cases were confirmed by virus isolation, 54 Flu B and 12 Flu A. Genotypification showed that isolates were genetically similar to Influenza B/Texas/4/2006 (n=34) and A/Texas/91/2007 (H3N2) (n=7). Most common symptoms found were fever, headache, malaise, cough, sore throat, myalgias and rinorrheae. Control strategies consisted to identify probable cases and to isolate them in a special room and to wear facemasks. [b][i]Conclusions.[/i][/b] We confirmed 66 cases by cellular culture. Isolates were genetically similar to influenza B/Texas/4/2006 and A/Texas/91/2007 (H3N2).
Authors and Affiliations
Tatiana Saldarriaga, V. Alberto Laguna-Torres , Juan Arrasco, Luis Guillén, Patricia Aguilar, Merly Sovero, Jane Ríos , María Gomero, Rommell González, Tadeusz Kochel
Keywords
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