Clinical and paraclinical features in children with febrile seizures
Journal Title: Dicle Tıp Dergisi - Year 2014, Vol 41, Issue 1
Abstract
Objective: The approach, diagnostic investigations, followup, and treatment in children presented with febrile seizures are still controversial. We aimed to determine the clinical characteristics, laboratory results, electroencephalography and neuroimaging findings, treatment modalities, and outcome at 1-year-long follow-up period in children presented with febrile seizures. Methods: A total of 269 children (109 females and 160 males) between the ages of 3 and 60 months who were referred to pediatric neurology department due to febrile seizures between July, 2011 and November, 2013 were enrolled into the study. Results: Mean ages at onset of the febrile seizures and at admission were 20.1±12.1 months and 29.2±15.3 months, respectively. A total of 154 (57.2%) patients had recurrent febrile seizures; 2 seizures in 80 (29.7%), 3 in 49 (18.2), and >3 in 25 (9.3%) patients. A history of febrile seizures and epilepsy among the first-degree relatives was obtained in 55(20.8%) and 37 (14.0%) patients, respectively. Six (2.2%) patients presented with febrile status epilepticus. Electroencephalography was performed in 180 (63.6%) patients, and revealed epileptic discharges in 18 (10%) children. Brain magnetic resonance imaging studies were carried out in 40 (14.9%) patients, of them, 6 (15.0%) had incidental nonspecific white matter lesions which were all irrelevant to seizures. Forty one (30.6%) patients were found to have anemia. Antiepileptic medication was initiated in 26 (9.7%) patients (phenobarbital in 8 and valproate in 18 patients); rectal diazepam was prescribed in the remaining 243 (90.3%) patients. The seizures were simple in 182 (67.7%) and complicated in the remaining 87 (32.3%) patients. At the end of 1-year of followup period, a diagnosis of epilepsy was made in 5 (4%) of 124 children who had all complicated and recurrent febrile seizures. Conclusion: Electroencephalography should be performed in children presented with complicated seizures, and patients those with epileptic discharges on electroencephalography should be given a close follow-up in regard to epilepsy development. The yield of neuroimaging is not contributory to the diagnostic and therapeutic approach. Key words: Febrile seizures, electroencephalography, epilepsy.
Authors and Affiliations
Ünsal Yılmaz, Rahmi Özdemir, Tanju Çelik, Emel Berksoy
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