Clinical and Physiological Effects of Exercise Training in Dyspneic Mild COPD Patients: Design of the Study
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 21, Issue 10
Abstract
Introduction: Mild chronic obstructive pulmonary disease (COPD) may be associated with physical inactivity, exercise limitation, and impaired health related quality of life, because of a combination of deconditioning, dyspnea, and reduced peripheral muscle mass. Although the benefits of exercise training (ET) in counteracting these consequences are well established in moderate-to-very-severe COPD, it is unclear if they are also effective in mild disease. The aim of this paper is to describe the design of a randomized controlled trial (RCT) to assess the efficacy of ET in patients with mild COPD and dyspnea, defined by a modified Medical Research Council dyspnea score ≥1. We hypothesize that their effectiveness will be similar to that observed in more advanced disease because of the presence of breathlessness. Consequently, ET will improve exercise limitation and health-related quality of life (HRQoL) in dyspneic mild COPD patients in comparison to usual care. Methods and Analysis: In this RCT, 60 mild dyspneic COPD patients (post-bronchodilator forced expiratory volume in 1 s [FEV1] ≥80% of predicted value and post-bronchodilator FEV1/ forced vital capacity [FVC] ≤70%) will be randomized to an intervention or usual care group. The intervention group will receive a 2-month ET program, which will include cycle exercise and muscle resistance training, whereas the control group will receive usual care. Primary outcome will be the change on the six-min walk test after ET. Secondary outcomes will include changes in HRQoL, assessed with the St. George’s Respiratory Questionnaire, and changes in exercise time during a constant load cycle exercise. Discussion: This will be the first RCT evaluating the efficacy of an ET program in patients with mild COPD. These results could be of relevance to clinical practice and develop new recommendation in mild disease. Clinical Trials.gov: NCT02930421.
Authors and Affiliations
Gonzalo Labarca, Andrea Bustamante, Francisco Rodríguez, Igor Nuñez, Paul Mac Nab, Álvaro Huete, Fernando Saldías, Orlando Díaz
Antioxidant and Anti-malarial Properties of Catechins
Aims: This research was performed to evaluate the antioxidant and anti malarial activities of various catechins including catechin (C), epicatechin (EC), catechin-gallate (CG), gallocatechin-gallate (GCG), epigallocatec...
Comparative Studies of Therapeutic Effect of Leaves, Stem Bark and Root Bark Extracts of Afzelia africana (Smith) in Mice Challenged with Trypanosoma brucei brucei
Background: Traditional and complimentary health care is inarguably the system most close to homes, accessible and affordable. It is also culturally acceptable and trusted by large numbers of people. The afford...
Post Neonatal Tetanus: 20 Years Experience as Seen at the University of Port Harcourt Teaching Hospital
Aims: To review the status of post neonatal tetanus at University of Port Harcourt Teaching Hospital with a view of highlighting the morbidity and mortality trend. Study Design: Retrospective descriptive study. Place and...
Effect of Vitamin C Supplementation on Learning and Memory in CD1 Mice
Vitamin C (ascorbic acid), an ‘over the counter’ supplement, has numerous physiological functions and it is found in high concentrations in the brain. The effect of vitamin C on cognitive memory and visuospatial memory w...
Comparing the Metal Concentration in the Nails of Healthy and Cancer Patients Living in the Malwa Region of Punjab, India with a Random European Group – A Follow up Study
The cancer prevalence in the Malwa region of Punjab (1089/million/year) is much higher than the national average cancer prevalence in India (800/million/year). In our previous study on hair metal analysis, we located a h...