Clinical aspects of hearing loss associated with cisplatin therapy – a review
Journal Title: Revista de Medicină Militară - Year 2014, Vol 0, Issue 3
Abstract
Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity. Material and methods: Experimental, clinical studies and reviews from the English language medical literature concerning ototoxicity were selected either from PubMed or printed medical journals, pointing out cisplatin-induced ototoxicity. Molecular mechanisms, clinical audiological and histological marks of cisplatin-induced ototoxicity as well as current experimental and clinical strategies for prevention or treatment of hearing loss were reviewed. Results and discussion: A wide range of otoprotective molecules and efficient strategies against cisplatin-induced hearing loss proved to be helpful in experimental studies whereas only dexamethasone settled a slight otoprotective effect in a clinical study. Conclusion: There is no currently available treatment for cisplatin associated hearing loss and further research is required for future therapeutic options.
Authors and Affiliations
Felician Chirtes
Keywords
Related Articles
- EP ID EP196613
- DOI -
- Views 100
- Downloads 0
Diagnosis and management of cases with deep infiltrating endometriosis affecting the urinary tract
Objective: The goal of this paper is to present the management of cases of deep endometriosis that affects the bladder, the ureters and the kidney. Materials and method: In this review we analyzed the sensitivity and sp...
Re-emerging infectious diseases: Ebola hemorrhagic fever
The spring of 2014 has brought a new calamity, the exotic infectious disease: Ebola Hemorrhagic Fever, which is caused by a highly contagious and pathogenic virus, transmitted directly by interpersonal contact or indirec...
Medical applications of the GC/MS method in the acute intoxication with dimethoate – clinical case
Mass spectrometry is a chemical analytical method of determining organic substances by comparing their mass spectrum with mass spectra found in system libraries. In the case of biological products, substances of interest...
The consequences of Chernobyl accident
These days marks 30 years since the Chernobyl nuclear accident, followed by massive radioactive contamination of the environment and human in Belarus, Ukraine and Russia, and resulted in many deaths among people who inte...
Capabilities for identification and confirmation of bacterial biological agents
Military Medical Service is able for detection, identification and confirmation of biological agents; it is part of medical protection against CBRN weapons. We are specialized capabilities for in vitro tests, under const...