Clinical aspects of hearing loss associated with cisplatin therapy – a review
Journal Title: Revista de Medicină Militară - Year 2014, Vol 0, Issue 3
Abstract
Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity. Material and methods: Experimental, clinical studies and reviews from the English language medical literature concerning ototoxicity were selected either from PubMed or printed medical journals, pointing out cisplatin-induced ototoxicity. Molecular mechanisms, clinical audiological and histological marks of cisplatin-induced ototoxicity as well as current experimental and clinical strategies for prevention or treatment of hearing loss were reviewed. Results and discussion: A wide range of otoprotective molecules and efficient strategies against cisplatin-induced hearing loss proved to be helpful in experimental studies whereas only dexamethasone settled a slight otoprotective effect in a clinical study. Conclusion: There is no currently available treatment for cisplatin associated hearing loss and further research is required for future therapeutic options.
Authors and Affiliations
Felician Chirtes
Salivary matrix metalloproteinases activity in periodontal disease
Introduction: Matrix metalloproteinases (MMPs) are key enzymes involved in degradation of extracellular colagen matrix during periodontal disease progression. The aim of our work was to study the levels of MMP-1, MMP-2,...
In memoriam – Brigadier General Mihai Nicolae Bînă
-
Stress management for optimization of organizational activity
Stress is a constant presence in our lives, whether we analyze it in professional, social or family terms. This daily reality creates a state of tension, strain and discomfort, causing significant changes in physical and...
Primary thyroid lymphoma – case report
Introduction. Even though, primary thyroid lymphoma (PTL) is a rare thyroid malignancy and extranodal non-Hodgkin lymphoma, this type of disease should not be disgraced in order to achieve an early diagnosis and multimo...
About clinical medicine: Is there still such a thing?
-