Clinical correlations between chronic hepatitis C infection and decreasing bone mass density after treatment with interferon-alpha
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 2
Abstract
Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a treatment. Methods: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evaluated. The treatment dosage was three million IU three times a week for one year. All the patients underwent bone mass density detection at lumbar spine and femoral neck before and after the interferon-a treatment. All the necessary information such as age, sex, and laboratory test, history of occurrence of fractures, lifestyle, and menopause status was collected by interviewers face-to-face from participants at the research visit. Smoking was categorized by whether participants were nonsmokers or smokers. Menopause was designated if there had been complete cessation of menses for more than 12 months. All statistical analyses were performed by SPSS version 14 (SPSS, Inc., Chicago, IL, USA). Results: Among 70 patients, 52% were male, 48% were female and the mean age was (57.0 ± 9.6) years (range: 24–79). Twenty-nine percent of the patients had a history of smoking. The mean body mass index was (24.4 ± 3.6) kg/m2 (range: 18.4–35.3). Of the 70 cases, 21 had high fibrosis-4. The prevalence of overall fracture history was 2.9% (two patients). Conclusions: Chronic hepatitis C virus infection did increase the risk of development of metabolic bone disease in this cohort. Indeed, greater reduction of bone mass density occurs in advanced liver fibrosis. The bone loss in earlier stages of chronic hepatitis C infection is likely to result from increased bone reduction rather than decreased bone formation. Overall, these observations suggest an important role for chronic hepatitis C virus infection in increased bone turnover in osteodystrophy pathogenesis.
Authors and Affiliations
Vahid Babaei, Masoud Ghorbani, Nastaran Mohseni, Hojjat Afraid, Yassaman Saghaei, Shahram Teimourian
Keywords
Related Articles
- EP ID EP247900
- DOI 10.1016/j.apjtb.2016.11.027
- Views 60
- Downloads 0
Antifungal and cytotoxic activities of extracts obtained from underutilised edible tropical fruits
Objective: To evaluate antifungal and cytotoxic activities of four underutilised fruit species, i.e. Artocarpus altilis (breadfruit), Cynometra cauliflora (nam-nam), Mangifera pajang (M. pajang) (Bambangan) and Physalis...
Analysis of chemical composition and bioactive property evaluation of Indian propolis
Objective To analyze the chemical composition and to evaluate the bioactive potential of hydroalocoholic extract of propolis. Methods Ethanol extract of propolis was analyzed by GC-MS, HPTLC and HPLC methods and in vi...
Cytotoxic, apoptotic and cell migration inhibitory effects of atranorin on SPC212 mesothelioma cells
Objective: To investigate the effects of atranorin, a lichen secondary metabolite, on SPC212 malignant mesothelioma cells in vitro. Methods: SPC212 malignant mesothelioma cell line was used. 3-(4,5-dimethylthiazol-2-yl)-...
A comprehensive review on phytopharmacological investigations of Acacia auriculiformis A.Cunn. ex Benth
Acacia auriculiformis A.Cunn. ex Benth. is a perennial shrub having a wide range of medicinal potentials and is widely distributed throughout the world. It is being used traditionally to overcome various medical complica...
Antibiotic susceptibility and molecular characterization of resistance genes among Escherichia coli and among Salmonella subsp. in chicken food chains
Objective: To investigate the occurrence of resistance genes among Escherichia coli (E. coli) and Salmonella subsp. isolated in chicken food chains in Phnom Penh, 2012–2013. Methods: Six hundred eighty two E. coli and 18...