Clinical efficacy of ursodeoxycholic acid in the comprehensive treatment of patients with obesity and gastroesophageal reflux disease
Journal Title: Гастроентерологія - Year 2018, Vol 52, Issue 4
Abstract
Background. Disorders in the body of patients with obesity have a systemic metabolic nature, including a negative impact on the state of the gastrointestinal tract. There was found a correlation between obesity and digestive diseases such as hepatic and pancreatic steatosis, gallstone disease, as well as gastroesophageal reflux disease (GERD). The administration of ursodeoxycholic acid (UDCA) as a part of comprehensive therapy of patients with obesity and GERD is pathogenetically justified, given its ability to influence metabolic processes in the body, as well as its protection of the mucous membrane of the upper gastrointestinal tract when exposed to aggressive refluxate. Objective: to study the clinical efficacy of the UDCA preparation (Ursofalk) in the comprehensive treatment of patients with obesity and GERD. Materials and methods. Ninety four patients with obesity of different classes and GERD were examined. They were divided into two clinical groups: group I (n = 44) received a standard treatment of GERD using a proton pump inhibitor against the background of lifestyle changes, compliance with dietary recommendations; group II (n = 50) in addition to the above-mentioned treatment received UDCA preparation Ursofalk (Dr. Falk Pharma GmbH, Germany) for 3 months. Results. GERD in patients with obesity is manifested by extraesophageal symptoms with an incidence of up to 40.9 % of cases. The prescription of proton pump inhibitor in combination with UDCA in obese patients leads to a significant reduction in heartburn, dysphagia, and extraesophageal manifestations of reflux disease by the end of weeks 2–4 of treatment. Comprehensive therapy using UDCA in the examined patients also contributed to a decrease in body weight (up to 5 kg per one month of treatment), mainly in obesity class І and ІІ. Conclusions. The use of Ursofalk in the comprehensive treatment of patients with GERD and obesity is a pathogenetically grounded mean for reducing and normalizing clinical manifestations of the disease, especially their extraesophageal forms. Comprehensive therapy of patients with GERD and obesity on the background of lifestyle modification and dietary recommendations should include UDCA preparation for faster, more effective and safe normalization of body weight with treatment duration of at least 3 months.
Authors and Affiliations
Ye. S. Sirchak
Keywords
Related Articles
- EP ID EP440800
- DOI 10.22141/2308-2097.52.4.2018.154140
- Views 90
- Downloads 0
Features of Histological Structure of the Esophagus and Stomach in Inflammatory and Erosive and Ulcerative Diseases of the Upper Gastrointestinal Tract, Associated with Mucosal Candidiasis
The study involved 84 patients with inflammatory and erosive and ulcerative diseases of esophagogastricarea, 72 of them — with Candida infection. It is found that typical histological features are dyskeratosis of esophag...
The Use of Essential Phospholipids for the Treatment of Fatty Liver Disease
Background. Given the similarity of histopathological pattern of non-alcoholic fatty liver disease and alcoholic liver disease, it was proposed to combine these both diseases in one nosological form named «fatty liver di...
Dynamics of Clinical and Biochemical Parameters in Patients with Liver Cirrhosis Under the Influence of Complex Therapy with Ursodeoxycholic Acid
It was studied dynamics of clinical and biochemical parameters in patients with liver cirrhosis under the influence of complex treatment using ursosan. It is found that the inclusion of ursosan in complex treatment impro...
Gallbladder Function and Hepatic Structural Changes in Children with Nonalcoholic Fatty Liver Disease
During the last decade, pediatric nonalcoholic liver disease has reached epidemic proportions, becoming one of the most frequent chronic liver diseases in the global child population. Purpose: to study the relationship o...
Place of Needle Biopsy in the Diagnosis of Chronic Diffuse Liver Diseases
The article deals with the diagnosis of chronic diffuse liver diseases. A brief review of noninvasive methods of diagnosis of liver fibrosis and percutaneous liver biopsy is given. A comparison has been carried out betwe...