CLINICAL EVALUATION OF ‘SUSPEND’ TRIAL WITH HERBAL PREPARATION AND TAMSULOSIN: A MEDICAL EXPULSIVE THERAPY FOR UROLITHIASIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 12
Abstract
Lithiasis occurs in various forms and at various sites in the body and the most common site is urinary tract. Urinary stones are one of the major problems and an important cause of morbidity and end stage renal failure in India. Urolithiasis affects up to 5 % of the population, with a recurrence rate of 50 to 80 %. Males are more frequently affected than the females. The objective of this study is to evaluate and compare the efficacy and safety of Herbal preparation (decoction of Boerhavia diffusa roots and Crataeva nurvala bark) and Tamsulosin in the treatment of patients with ureteric stones. A total of 110 patients with ureteric stones ranged from 4- 10 mm were selected for the trial according to the inclusion and exclusion criteria of this study and were randomized into two groups where the first group (herbal group) included 55 patients treated with decoction of Boerhavia diffusa roots and Crataeva nurvala bark in the dose of 50 ml BD daily, and the second group (tamsulosin group) included 55 patients treated with tamsulosin 0.4 mg/day. All patients were randomly assigned to receive the designed SUSPEND trial (Spontaneous Urinary Stone Passage enabled by Drugs) for a maximum of 6 weeks. The Herbal preparation found statistically significant in increasing the expulsion rate, better control of ureteric pain and reduced expulsion time of ureteric stone impacted in any part of the ureter i.e. the upper, middle and lower ureteric tract and thereby decrease in number of URS procedure performed to remove the stone of unaffected patients. Tamsulosin group results in a better control of ureteric pain and reduced expulsion time of stones which are impacted in only lower ureter.
Authors and Affiliations
Shyam Gupta , Vishal Khanna , Geetanjali Gupta , Ankush Bhardwaj , Anjali Sharma
Keywords
Related Articles
- EP ID EP121900
- DOI 10.7897/2230-8407.0512185
- Views 102
- Downloads 0
THERAPEUTIC STRATEGIES FOR THE TREATMENT OF PERIODONTITIS
Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by groups of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized. The concept that localized p...
EVALUATION OF NIMBA TAILA AND MANJISTHA CHURNA IN NON HEALING ULCER
This clinical study was done in fifty-one cases of non-healing ulcers of more than six weeks duration to evaluate the efficacy of Nimba taila (Neem oil) externally and Manjistha churna (powder) orally as well as its kwat...
PHYTOCHEMICAL SCREENING OF ARDISIA BLATTERI GAMBLE: AN ENDEMIC PLANT OF SOUTHERN WESTERN GHATS, TAMIL NADU, INDIA
The genus Ardisia Sw (coralberry or marlberry). is the largest genus in the family Myrsinaceae and comprises approximately 500 species distributed throughout subtropical and tropical regions of the world. This genus is a...
OBSESSIVE COMPULSIVE DISORDER: A REVIEW
Obsessive-Compulsive Disorder (OCD) is a type of anxiety disorder which can vary from being very mild to being very severe. From feeling compelled to wash your hands, to keep fixating your thoughts on one particular thin...
A COMPREHENSIVE STANDARDIZATION STUDY OF A POLY HERBAL FORMULATION: URAL TABLET
More than half the world’s population is dependent on herbal drugs and in order to enter into the global market it is vital to maintain the quality. Initially the crude drugs were identified by comparison only with the s...