CLINICAL EVALUATION OF THE THERAPEUTIC USE OF ORAL PROBIOTIC STREPTOCOCCUS SALIVARIUS K12 FOR RECURRENT PHARYNGITIS AND/OR TONSILLITIS
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 9
Abstract
The most important and common bacterial cause of pharyngeal infections in humans is Streptococcus pyogenes. The oral probiotic Streptococcus salivarius K12 has been studied and shown that it clearly antagonizes the growth of Streptococcus pyogenes by releasing two bacteriocins, salivaricin A2 and salivaricin B. This oral probiotic is quite safe and because of its ability to colonize the oral cavity, we have studied its efficacy in reducing the incidence of streptococcal pharyngitis and/or tonsillitis.The study included 34 patients with recurrent streptococcal pharyngitis or tonsillitis, aged between 12 years old and 45 years old. 20 patients were treated daily for 90 days with an oral slow-release tablet containing five billion colony-forming units of S. salivarius K12 (Bactoblis®), and 14 patients selected as untreated control group. 10 healthy patients were used as an additional control group. After 3 months of treatment, a 3-month follow-up period without treatment was included to evaluate a possible persistent protective role for the previously administered product. The patients who completed the 3-month course of Bactoblis showed a dramatic decrease in their episodes of streptococcal pharyngeal infection (about 95%) comparing infection episodes with the previous year. Patients tolerated the product well, with no side effects reported. Prophylactic administration of S. salivarius K12 to patients with a history of recurrent oral streptococcal pathology decreased the episodes of streptococcal pharyngeal infections and/or tonsillitis.
Authors and Affiliations
Taylan Gun
Keywords
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