Clinical factors affecting the perception of hypoglycemia in type 1 diabetes patients treated with personal insulin pumps
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 20, Issue 1
Abstract
Introduction and Objective. The ability to perceive the symptoms of hypoglycemia during the early decrease in plasma glucose concentration may be critical for the safety of T1DM patients treated with intensive insulin therapy, including those treated with continuous subcutaneous insulin infusion (CSII). In the presented observational study an attempt was made to asses clinical factors that might affect subjective awareness of hypoglycemia in CSII-treated T1DM patients, with special attention to factors specific for this mode of treatment.Materials and Methods. For the purpose of the study, data of 110 CSII-treated T1DM patients were collected (78 females and 32 males). The records were analyzed from glucose meters (200-300 measurements/download, depending on meter type) and insulin pumps (total insulin dose, basal/bolus ratio, number of boluses/day, bolus calculator and dual wave/square bolus usage, continuous glucose monitoring data) from the last 3 years.Results. It was found that the level of subjective hypoglycemia perception inversely correlated with the number of hypoglycemic episodes per 100 measurements, age, duration of diabetes, time on insulin pump, and positively correlated with mean glycemia (n = 98; r = 0.22; p = 0.0286). With respect to CSII-related factors, hypoglycemia perception inversely correlated with the percentage of basal insulin (n = 106; r = -0.20; p = 0.0354). In stepwise regression analysis, independent predictors for impaired hypoglycemia perception were: age β = -0.29 (p = 0.023), duration of diabetes β = -0.24 (p = 0.029) and number of the hypoglycemia episodes for 100 measurements β = -0.33 (p = 0.0005).Conclusions. Risk factors for impaired hypoglycemia perception in CSII-treated patients include those identified previously for the general population of T1DM individuals. In addition, the presented results suggest that a higher basal/bolus ratio may lead to impairment of the ability to perceive early symptoms of hypoglycemia.
Authors and Affiliations
Bartłomiej Matejko, Małgorzata Grzanka, Beata Kieć-Wilk, Maciej Małecki, Tomasz Klupa
Keywords
Related Articles
- EP ID EP80595
- DOI -
- Views 157
- Downloads 0
Association of socio-economic and demographic factors with physical activity of males and females aged 20–69 years
[b]Objective[/b]. To assess the physical activity of working residents of Warsaw aged 20–69 years, as well as to identify the socio-demographic factors associated with their levels of physical activity. [b]Materials an...
Effects of aerobic interval training versus continuous moderate exercise programme on aerobic and anaerobic capacity, somatic features and blood lipid profile in collegate females
introduction. Regular physical activity has many positive health benefits, including reducing the risk of cardiovascular diseases, metabolic diseases and some cancers, as well as improving the quality of life. objectiv...
Seroprevalence of Lyme disease and genospecies of [i]Borrelia burgdorferi[/i] sensu lato in patients diagnosed with borreliosis in the Province of Warmia-Masuria in north-eastern Poland
Between 2009-2010, a group of 259 patients suspected of contracting Lyme disease were examined in the Provincial Sanitary-Epidemiological Station in Olsztyn for the presence of IgM and IgG against specific [i]Borrelia bu...
Microarrays – new possibilities for detecting biological factors hazardous for humans and animals, and for use in environmental protection
Both the known biological agents that cause infectious diseases, as well as modified (ABF-Advanced Biological Factors) or new, emerging agents pose a significant diagnostic problem using previously applied methods, both...
Total hip arthroplasty in the treatment of degenerative disorders in rural and urban patients – A retrospective, randomised and controlled study
[b]Introduction[/b]. Farming is hard work which may lead to overstrain and osteoarthritis of the hip and knee. Hip osteoarthritis has been rarely discussed in the Polish literature. objective. The objective of the stud...