Clinical features and prognostic factors of early breast cancer at a majorcancer center in North India.
Journal Title: Indian Journal of Cancer - Year 2005, Vol 42, Issue 1
Abstract
BACKGROUND: Data on the clinical profile of early breast cancer (EBC) fromIndia is scant. Due to differences in genetics, environment, lifestyle, socio-demographic structure andethnicity, the presentation and behavior of breast cancer in India may be different. AIMS: To analyzethe clinical presentation and outcome of EBC patients. SETTINGS AND DESIGN: A single center retrospectivestudy. MATERIALS AND METHODS: Data from 487 EBC patients registered and treated at our institute from1993 through 1999 were analyzed. Cox's multivariate regression test was used to determine prognosticfactors for overall and disease-free survival (OS & DFS). RESULTS: The median age was 47 years and 49.7%patients were pre-menopausal. Ninety-six per cent patients presented with a lump. Stages I, IIa, andIIb comprised 7.8%, 38.8%, and 47.6% respectively. Only 11.3% patients opted for breast-conserving surgery(BCS) while the remaining 88.7% underwent modified radical mastectomy (MRM). Adjuvant chemotherapy wasadministered to 275 (56.5%), and radiotherapy to 146 (29.9%). Estrogen receptor status was known in 173,of whom 93 (53.7%) were positive. Most patients were prescribed Tamoxifen for 5 years. At a median follow-upof 48 months, 126 (25.9%) patients had relapsed (systemic 107, loco-regional 19) and 94 (19.3%) had died.Five-year DFS and OS were 73% and 78%, respectively. On multivariate analysis, four positive nodes adverselyinfluenced survival (P< 0.01). CONCLUSIONS: The median age at presentation was 47 years, significantlylower than most Western figures. The majority (86.4%) had a lump size > two cm. BCS was done in only11% and the rest underwent MRM. Nodal involvement was the significant prognostic factor.
Authors and Affiliations
Vinod Raina, Manisha Bhutani, Rajeev Bedi, Atul Sharma, Suryanarayana V Deo, Nootan K Shukla, Bidhu Kalyan Mohanti, Goura K Rath
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Clinical features and prognostic factors of early breast cancer at a majorcancer center in North India.
BACKGROUND: Data on the clinical profile of early breast cancer (EBC) fromIndia is scant. Due to differences in genetics, environment, lifestyle, socio-demographic structure andethnicity, the presentation and behavior of...