Clinical Features of Acute Respiratory Viral Infections in Infants with Thymomegaly
Journal Title: Здоров`я дитини - Year 2016, Vol 1, Issue 69
Abstract
Introduction. Peculiarities of acute respiratory viral infections (ARVI) in children with increased size of the thymus are associated with the presence of more or less significant immunodeficiency and dyshormonosis with manifestations of adrenal insufficiency. Objective — to study the features of acute respiratory viral infections and to investigate adrenal function in infants with thymomegaly. Material and methods. 41 children aged 1 month to 3 years with thymomegaly and complicated forms of ARVI were involved in clinical studies. Etiological decoding of ARVI has been carried out with the use of paired serum samples. The content of cortisol in the blood plasma was determined by immunoenzyme method. 36 children with thymomegaly without ARVI manifestations within at least 3 months were in comparison group. Results. Analysis of the anamnesis in patients with thymomegaly showed that most of them experienced adverse conditions at different stages of antenatal, intrapartum and postnatal development. Analysis of the data on the size of the thymus gland showed that 3rd — 4th degree of thymomegaly is often observed in children with signs of constrictive laryngotracheitis (75.0 %). 23.5 % of patients with obstructive bronchitis had 1st degree thymomegaly, the rest — 3rd and 4th degrees. In case of nonobstructive lesions of the bronchi, the opposite trend took place: the least degree of thymomegaly was diagnosed in 62.5 %, and 3rd and 4th — in 37.5 % (p < 0.05) of patients. The lowest supply of cortisol was noted in the acute period of constrictive laryngotracheitis (409.4 ± 10.2 nmol/ml against 537.7 ± 11.5 nmol/ml in the comparison group; p < 0.05). In the acute period of ARVI complicated by bronchitis, cortisol levels were not increased — 432.3 ± 32.3 nmol/ml. In the group of patients with pneumonia, we have recorded reliable, probably compensatory increase of cortisol level (787.3 ± 2.0 nmol/ml, p < 0.05). In the acute period of obstructive bronchitis, only tendency towards increasing of cortisol concentration in the blood (562.9 ± 18.9 nmol/ml) was observed. Restoration of adrenocortical function during recovery of infants with thymomegaly was inhomogeneous too. Parameters of children who recovered from acute bronchitis were most significantly closer to physiological parameters. Cortisol supply in patients with pneumonia at the time of recovery did not differ from baseline in children with thymomegaly. The amount of cortisol increased fastest in the dynamics of constrictive laryngotracheitis (up to 528.5 ± 22.6 nmol/ml). Conclusion. Children with thymomegaly are at risk for the development of bronchopulmonary complications of acute respiratory viral infections.
Authors and Affiliations
T. V. Sorokman, S. V. Sokolnyk, M. I. Polishchuk, O. -M. V. Popelyuk
Keywords
Related Articles
- EP ID EP197582
- DOI -
- Views 97
- Downloads 0
Review of the Meeting of the Board of Experts in the Field of «Pediatric Gastroenterology and Nutrition»
The article presents the review of the meeting of the board of experts in the field of «Pediatric gastroenterology and nutrition», which took place on November 28–29, 2015 in Truskavets, as well as the resolution adopted...
Vascular-Rheological Properties of Blood in Hemorrhagic Vasculitis Occurring in Childhood and Adulthood
Background. As a result of the immune-inflammatory necrotic changes in the walls of arterioles and capillaries in patients with hemorrhagic vasculitis (HV) Henoch — Schönlein endothelial dysfunction of vessels occurs, co...
Factors of Formation of Various Types of Left Ventricular Diastolic Filling in Adolescents with Myocardium Pathology
Objective: to study the main components of the formation of impaired left ventricular diastolic filling in adolescents with myocardial pathology. Materials and methods. The study involved 110 adolescents with myocardial...
The morpho-functional features of the left ventricular myocardium and common carotid arteries in children with cystic fibrosis
Background. The features of the morpho-functional state of the left ventricular myocardium and common carotid arteries were studied according to echocardiography in children with cystic fibrosis. Materials and methods. 7...
Dysmetabolic nephropathy as a risk factor of pylonephritis in children
Background. Dysmetabolic nephropathies contribute to the development of urinary stone disease in children, the emergence of an infection of the urinary system, secondary pyelonephritis and formation of tubulo-interstitia...