Clinical genetics of stomach cancer
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 11
Abstract
Gastric cancer (GC) is one of the most frequently diagnosed malignancies of the gastrointestinal tract. Familial aggregation of stomach cancer in about 20% of all diagnosed cases suggests that in these families stomach cancer is caused by genetic predisposition. Stomach cancer has been shown to be part of the tumour spectrum in other inherited complexes, including hereditary non-polyposis colon cancer (HNPCC), familial adenomatous polyposis (FAP), Cowden's complex, Peutz-Jeghers complex, Li-Fraumeni complex and Bloom's complex.The only complex of genetic predisposition to familial gastric cancer is characterized by detection of E-cadherin (CDH1) gene mutations in early onset cases diagnosed with diffuse gastric cancer. Along with substantially increased risk of diffuse gastric cancer, in families with detected CDH1 mutation, lobular breast cancer, colon cancer and prostate cancer have been reported. Because of the very high penetrance of CDH1 mutations and lack of effective methods in detection of early gastric cancer, prophylactic gastrectomy is recommended to all CDH1 carriers.Up to now it is not known have to deal with patients from families with gastric cancer aggregation. Except of families with detected CDH1 mutations there is a lack of surveillance protocols for patients with recognized hereditary gastric cancer. In most centres is recommended annual gastroscopy in all relatives starting 5-10 years earlier than the youngest age of diagnosis of family with aggregation of GCs. However, the most appropriate prophylactic and medical treatment for GC patients from families with recognized genetic predisposition can be determined after extended analyses on large patients group.
Authors and Affiliations
Anna Jakubowska, Beata Wojnarska, Urszula Teodorczyk, Jan Lubiński
Keywords
Related Articles
- EP ID EP53789
- DOI -
- Views 173
- Downloads 0
Perception of anti-vaccination movements by parents of young children
Introduction. The realization of the immunization program remains in Poland on a high level, but a number of parents who decline vaccinations systematically increases.Aim. The aim of the study was to learn opinions and p...
Wiedza rodziców o gorączce i o zasadach postępowania w przypadku jej wystąpienia u dzieci do 12 roku życia
Wstęp. Gorączka jest często pierwszym objawem infekcji wirusowej czy bakteryjnej. Pierwszymi osobami, które stwierdzają podwyższoną ciepłotę ciała u dziecka są rodzice, którzy są odpowiedzialni za racjonalne leczenie prz...
Nefropatia cukrzycowa 2010 – zapowiedź zmian w praktyce klinicznej?
Opublikowane w ostatnim czasie dane dotyczące patogenezy zmian kłębuszkowych w cukrzycy oraz wyniki kontrolowanych dużych badań klinicznych wskazują na istotną rolę optymalnej kontroli glikemii dla prewencji nefropatii c...
Vitamin D deficiency is common in orthopaedic ward staff
Introduction. Vitamin D deficiency is common in many populations and its health are not limited to bone.Aim. To determine vitamin D concentrations at its minimum in orthopaedic ward staff.Material and methods. In early s...
Impact of atrovastatin and perindopril on the hair cycle in rodent model – risk of drug induced alopecia in patients with heart disease
<b>Introduction. </b>Adverse drug reactions play an important role. Often they are severe, impact many organs and further treatment is always determined by their occurrence. One of them is dru...