Clinical Indications of Hematopoietic Stem Cell Transplantation: A Clinical Review
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 3
Abstract
Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor cells that develop from mesodermal hemangioblast cells. All differentiated blood cells from the lymphoid and myeloid lineages arise from HSCs. HSCs can be found in adult bone marrow, peripheral blood, and umbilical cord blood. Classic studies in mice describe two populations of Hematopoietic Stem Cells, Long Term and Short Term. Long term HSCs are capable of self renewal, while short term HSCs do not have this capacity. Short term HSCs, also called progenitor or precursor cells, can differentiate into all types of blood cells, which can be characterized by specific markers. Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of autologous or allogeneic stem cells collected from bone marrow, peripheral blood, or umbilical cord blood to reestablish hematopoietic function in patients with damaged or defective bone marrow or immune systems. HSCT is used throughout this article as a general term covering transplantation of progenitor/stem cells from any source (e.g., bone marrow, peripheral blood, and cord blood). Interpretation of the results of trials of bone marrow transplantation is always complicated by the problem of patient selection. The efficacy of transplantation can be underestimated if only patients with the worst prognoses are studied, or it can be overestimated if only those with the best prognoses are studied. HSCT has led to the cure of diverse forms of cancer, bone marrow failure, hereditary metabolic disorders, and severe congenital immunodeficiency’s that would otherwise have been fatal. The indications for HSCT vary according to disease categories and are influenced by factors such as cytogenetic abnormalities, response to prior therapy, patient age and performance status, disease status (remission vs. relapse), disease-specific prognostic factors, and, most importantly, availability of a suitable graft source. The aim of present article is to provide in depth knowledge about Hematopoietic stem cell transplantation (HSCT) as well as various clinical indications of HSCT.
Authors and Affiliations
Satyanand Tyagi*| President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India -302020., Asheesh Parihar| Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114., Tarun Parashar| Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248001, Soniya| Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248001
Keywords
Related Articles
- EP ID EP1556
- DOI -
- Views 385
- Downloads 24
BRINE SHRIMP LETHALITY TEST AND ANTI-PROLIFERATION TEST AGAINST HUMAN CANCER-ORIGIN CELL LINES USING ETHANOLIC AND WATER EXTRACTS OF SELAGINELLADOEDERLEINII HIERON
Most of the properties of herbal products claimed in traditional use are based on traditional knowhow and/or empirical observations. Support from scientific evaluation and validation is thus crucial. Selaginella doederle...
Pharmacognostic Standardization and HPTLC Analysis of the Roots of Aerva ambigua/Aerva leucura
Morphoanatomy of the roots of Aerva leucura plant has been studied with the aim to aid pharmacognostic, phytochemical analysis by using WHO recommended physico-chemical determinations and authentic phytochemical procedur...
PERINATAL OUTCOMES ASSOCIATED WITH MECONIUM STAINED NON VIGOROIUS BABIES IN A TERTIARY CENTRE OF UTTARAKHAND (INDIA)
We examined the perinatal outcomes in singleton pregnancies associated with meconium-stained amniotic fluid (MSAF) in non vigorous neonates.The study was performed during one year (2012-2013) in new borns admitted at o...
Seroprevalence of Herpes Simplex Virus (HSV-1 and HSV-2) Infections in Sudanese Renal Transplant Recipients
Introduction: Viruses are among the most common causes of opportunistic infections after transplantation, because of their immunosupressed condition. Aim: This study aimed to determine Herpes Simplex Virus-1 and Herpes...
Influenza Virus Co-Circulation and Emergence of New Variants.