Clinical observation of 36 patients with chronic nephritis proteinuria treated with Zhuangshen Gujing decoction
Journal Title: TMR Clinical Research - Year 2020, Vol 3, Issue 3
Abstract
Objective: Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis. Methods: 72 patients with chronic nephritis proteinuria were divided randomly into two groups; one group was treated with Zhuangshen Gujing (n = 36; treatment group) and the other group was treated with irbesartan (n = 36; control group). After 6 months’ treatment, urine protein and renal function were evaluated. Results: Proteinuria resolved completely in four patients in the treatment group; complete disease resolution was observed only among three individuals in the control group. Of the 32 cases remaining in the treatment group, 15 had substantial responses to Zhuangshen Gujing decoction, 9 had partial responses, and 8 had no response to treatment; the overall the response rate was 73.33%. Among the 33 cases remaining in the control group, 12 had a substantial response to irbesartan, 5 had a partial response, and 16 had no response to treatment; the overall response rate among the controls was 57.67% (P = 0.031). We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment (P = 0.001). Conclusion: Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.
Authors and Affiliations
Li-Chang Liu1*, Xin Liu1, Qi Huang1, Wei-Hong Hong1, Min-Jian Feng1, Yu-Yan Jin1, Xue-Fei Du1
Keywords
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- EP ID EP686551
- DOI 10.12032/TMRCR20200706012
- Views 183
- Downloads 0
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