Clinical Outcome in down Syndrome Children with Congenital Heart Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 7, Issue 4
Abstract
Aims: Down syndrome (DS) is the most common chromosome abnormality among live born infants. The aim of this study is to determine the Clinical outcome of patients with DS and congenital heart disease (CHD). Study Design: A cross-sectional study. Place and Duration of Study: On 100 patients with DS and CHD who underwent diagnostic and therapeutic work up in the pediatric cardiology department from September 2001 through September 2012 in Imam Reza hospital (Mashhad, Iran). Methodology: All data collected according to a designed checklist. Most of these patients had previous history of admission in the pediatric cardiology ward. Some of these data were derived from the patient's file. Others data got by taking a history from the parents of patients and direct follow up of the patients by pediatric assistant and echocardiography by a pediatric cardiologist. Surgery was done in Imam Reza hospital. Palliative surgeries include Pulmonary Artery Banding (PAB) +/- PDA closure (if the PDA was present) and total corrections include complete correction of the defect such as ASD closure, VSD closure and repair of other defects. Medical treatments include Digoxin, Captopril, Sildenafil and Propranolol which were administered based on the type of disorders. Independent t-test, and Chi-square test were used to compare quantitative and qualitative variables between groups, respectively. Data analysis was done with SPSS ver. 11.5 and P<0.05 was considered as statistically significant. Results: The mean age of CHD diagnosis was 3.10±2.52 months and mean age of refer to pediatric cardiologist was 5.46±8.60 months. 52% of subjects were females. 50 patients underwent surgical therapy and 50 patients underwent non-surgical therapy (Medical therapy). Of 100 patients, 43(43%) patients were expired, 36(36%) patients had improved signs, and complications were detected in 25(43.85%) of live patients. The mean age of death in patients was 15.24±11.69 months. The Pulmonary Arterial Pressure (PAP (decreased in 68.4 percent of patients after surgical therapy and 16.6 percent of patients with non-surgical therapy. There is a significant correlation between the type of therapy and PAP after treatment (P=.001). Complications of CHD were detected in 8 patients of the surgical group (27.58% of live patients), 5(33.33%) patients of non-surgical (Medical therapy) group and in 12(92.3%) the refusing surgery group. Conclusion: The early diagnosis and therapeutic intervention especially cardiac surgery is critical in this group.
Authors and Affiliations
Hassan Mottaghi Moghaddam, Mohammad Hassan Nezafati, Toktam Sheykhian, Maliheh Dadgarmoghaddam
Keywords
Related Articles
- EP ID EP347836
- DOI 10.9734/BJMMR/2015/15098
- Views 69
- Downloads 0
Utility of GenoType MTBDRPlus Assay for Direct Detection and Drug Susceptibility Testing of Mycobacterium tuberculosis from Probable Tuberculous Meningitis Patients
Aims: To evaluate GenoType® MTBDRplus line probe assay as a diagnostic tool for detection of Mycobacterium tuberculosis and drug susceptibility testing from cerebrospinal fluid of probable tuberculous meningitis patient...
Hematological and Immunological Effect of Cannabis sativa on Albino Wistar Rats
The present study is aimed at ascertaining the effect of oral feeding of Cannabis sativa on blood parameters and immunity in rats. Administration of Cannabis sativa was done by orogastric feeding. All the groups had fre...
A Case of Diffuse Pulmonary Calcification with Multiple Myeloma
A 40 year old male with a 4-year history of multiple myeloma (MM) had recurrent episodes of extensive bone involvement. A 99mTc-MDP bone scan revealed unusual radiotracer accumulations within bilateral pulmonary fields....
Writing on One’s Own Demise: Suicide Notes in the Age of the Internet
One to two people out of six who attempt suicide will leave a note behind. In comparison to notes written on paper, internet suicide notes may differ in a variety of characteristics, as they illustrate different degrees...
Accuracy of Blood Loss Determination after Vaginal Delivery: Visual Estimation versus Calibrated Measurement
Background: The ability to determine accurately, the blood loss during childbirth is of extreme importance in the diagnosis and management of primary postpartum haemorrhage (PPH). Aims: In this study, we evaluate the eff...